Studies into the allosteric regulation of α-isopropylmalate synthase

Studies into the allosteric regulation of α-isopropylmalate synthase

α-Isopropylmalate synthase (α-IPMS) catalyses the first committed step in leucine biosynthesis in bacteria, including Neisseria meningitidis and Mycobacterium tuberculosis. It catalyses the condensation of α-ketoisovalerate (α-KIV) and acetyl coenzyme A (AcCoA) to form α-isopropylmalate (α-IPM). Lik...

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Bibliographic Details
Main Author: Huisman, Frances Helen Adam
Language:en
Published: University of Canterbury. Chemistry Department 2013
Subjects:
α-Isopropylmalate synthase
α-IPMS
LeuA
allosteric regulation
allosteric inhibition
regulatory domain
leucine
enzyme
Online Access:http://hdl.handle.net/10092/7599

Internet

http://hdl.handle.net/10092/7599

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