The association between immune response genes and apolipoprotein E (ApoE) related genes in the predisposition for Alzheimer's disease.

• Other Authors: Ma, Suk Ling.
• Format: Others
• Language: English; Chinese
• Published: 2003
• Subjects: Alzheimer Disease > etiology; Alzheimer Disease > pathology; Alzheimer Disease > ethnology; Apolipoproteins E > genetics; Genotype; Risk Factors
• Online Access: http://library.cuhk.edu.hk/record=b5891456; http://repository.lib.cuhk.edu.hk/en/item/cuhk-324511

by Ma Suk Ling. === Thesis (M.Phil.)--Chinese University of Hong Kong, 2003. === Includes bibliographical references (leaves 106-129). === Abstracts in English and Chinese. === Abstract --- p.i === 摘要 --- p.iii === Acknowledgements --- p.v === Publications --- p.vi === Abbreviations --- p.vii === Chapter Chapter 1 --- General Introduction --- p.1 === Chapter 1.1 --- Epidemiology of AD --- p.2 === Chapter 1.2 --- Clinical and pathological features of AD --- p.3 === Chapter 1.2.1 --- Clinical features of AD --- p.3 === Chapter 1.2.2. --- Pathological features of AD --- p.3 === Chapter 1.3 --- Diagnosis of AD --- p.4 === Chapter 1.4 --- Classification of AD --- p.5 === Chapter 1.5 --- Causes of AD --- p.5 === Chapter 1.6 --- Risk factors --- p.5 === Chapter 1.6.1 --- Age --- p.5 === Chapter 1.6.2 --- Family history --- p.6 === Chapter 1.6.3 --- Genetics --- p.6 === Chapter 1.6.3.1 --- Autosomal dominant mutations --- p.6 === Chapter 1.6.3.2 --- Genotypes of Apolipoprotein E --- p.6 === Chapter 1.6.4 --- Environmental factors --- p.7 === Chapter Chapter 2 --- Pathology in Alzheimer's disease --- p.8 === Chapter 2.1 --- Overview of Alzheimer's disease pathology --- p.8 === Chapter 2.2 --- Amyloid plaques --- p.8 === Chapter 2.2.1 --- Amyloid precursor protein --- p.8 === Chapter 2.2.2 --- Processing ofAPP --- p.9 === Chapter 2.2.3 --- Amyloid β (Aβ) --- p.12 === Chapter 2.2.4 --- APP mutations and AD --- p.12 === Chapter 2.3 --- Neurofibrillary tangles (NFT) --- p.15 === Chapter 2.3.1 --- Tau --- p.15 === Chapter 2.3.2 --- Tau mutation and neurodegeneration --- p.17 === Chapter 2.4 --- Hypotheses for AD pathology --- p.18 === Chapter 2.4.1 --- Amyloid cascade hypothesis --- p.18 === Chapter 2.4.2 --- Inflammatory hypothesis --- p.20 === Chapter 2.4.2.1 --- Microglia and astrocytes --- p.21 === Chapter 2.4.2.2 --- Inflammatory cytokines --- p.23 === Chapter 2.4.2.3 --- Inflammation and AD --- p.25 === Chapter 2.4.3 --- ApoE hypothesis --- p.27 === Chapter 2.4.3.1 --- Apolipoprotein E --- p.27 === Chapter 2.4.3.2 --- ApoE and AD --- p.28 === Chapter 2.5 --- Theory towards the pathology of AD --- p.30 === Chapter Chapter 3 --- ApoE genotyping --- p.32 === Chapter 3.1 --- Introduction --- p.32 === Chapter 3.2 --- Materials and methods --- p.32 === Chapter 3.2.1 --- Patients and control subjects --- p.32 === Chapter 3.2.2 --- Blood sampling --- p.33 === Chapter 3.2.3 --- DNA genotyping --- p.34 === Chapter 3.2.4 --- Statistical analysis --- p.35 === Chapter 3.3 --- Results --- p.35 === Chapter 3.. --- Discussion --- p.38 === Chapter Chapter 4 --- IL-1β polymorphism in relation to the risk of ADin Chinese --- p.39 === Chapter 4.1 --- Introduction --- p.39 === Chapter 4.2 --- Materials and methods --- p.44 === Chapter 4.2.1 --- Patients and control subjects --- p.44 === Chapter 4.2.2 --- Blood sampling --- p.44 === Chapter 4.2.3 --- DNA genotyping --- p.44 === Chapter 4.2.4 --- Statistical analysis --- p.48 === Chapter 4.3 --- Results --- p.48 === Chapter 4.4 --- Discussion --- p.53 === Chapter Chapter 5 --- TNFα polymorphism in relation to the risk of ADin Chinese --- p.63 === Chapter 5.1 --- Introduction --- p.63 === Chapter 5.2 --- Materials and methods --- p.66 === Chapter 5.2.1 --- Patients and control subjects --- p.66 === Chapter 5.2.2 --- Blood sampling --- p.66 === Chapter 5.2.3 --- DNA genotyping --- p.66 === Chapter 5.2.4 --- Haplotype determination --- p.70 === Chapter 5.2.5 --- Statistical analysis --- p.70 === Chapter 5.3 --- Results --- p.70 === Chapter 5.4 --- Discussion --- p.75 === Chapter Chapter 6 --- LRP8 polymorphism in relation to the risk of ADin Chinese --- p.81 === Chapter 6.1 --- Introduction --- p.81 === Chapter 6.2 --- Materials and methods --- p.87 === Chapter 6.2.1 --- Patients and control subjects --- p.87 === Chapter 6.2.2 --- Blood sampling --- p.87 === Chapter 6.2.3 --- DNA genotyping --- p.87 === Chapter 6.2.4 --- Statistical analysis --- p.89 === Chapter 6.3 --- Results --- p.91 === Chapter 6.4 --- Discussion --- p.98 === Chapter Chapter 7 --- Conclusions and prospects for future work --- p.102 === Chapter 7.1 --- Conclusion --- p.102 === Chapter 7.2 --- Prospects for future work --- p.105 === Reference --- p.106