Mechanisms of genetic regulation of IGF1 expression.
類胰島素生長因子1(IGF1)是一種負責代謝、細胞生長、身體發展的多肽激素。微衛星和單核苷酸多態性(SNP), 與循環IGF1水平顯著相關。然而,目前沒有研究指出微衛星和SNPs的綜合影響,且這些遺傳變異對IGF1的調控機制仍是未知。本研究的假設是,微衛星和SNPs在啟動子區域可能有相互作用從而調控IGF1水平。因此,本研究的目的是找出影響IGF1表達的主要元素,並研究每個基因變異的作用。 === 在這項研究中,整個IGF1的基因,包括上游和下游的5萬鹼基對(bp),可分為4個單體型區段,而IGF1的調控區在第3和第4個區段。與其它重復序列的微衛星相比,有21個重復序列的微衛星(IGF1上游9...
Other Authors: | Chen, Yu Holly. |
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Format: | Others |
Language: | English Chinese |
Published: |
2012
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Subjects: | |
Online Access: | http://library.cuhk.edu.hk/record=b5549545 http://repository.lib.cuhk.edu.hk/en/item/cuhk-328122 |
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