BRE attenuates apoptosis through maintaining the cellular level of an apoptotic inhibitor XIAP.
以前的研究表明,BRE是一種能在內源和外源凋亡路徑中均發揮作用的抗凋亡蛋白。然而,我們卻完全不知道它發揮抗凋亡功能的分子機制和生物化學機制是怎樣的。在本論文中,我們報導了BRE通過保護細胞內的XIAP水準來發揮抗凋亡功能。XIAP是一種強大的內源性的半胱氨酸天冬氨酸蛋白酶的抑制劑,與BRE一樣,XIAP也在內源和外源凋亡路徑中均發揮作用。 === 我們使用鼠Lewis細胞系為母細胞系,產生了shRNA介導的BRE基因敲除穩定細胞系。我們發現這種BRE敲除細胞系使得細胞對於在即使沒有放線菌酮作用下的腫瘤壞死因數α介導的凋亡也異常敏感。放線菌酮通過抑制抗凋亡蛋白的合成以發揮重要的促凋亡作用,相反地...
Other Authors: | Li, Wei. |
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Format: | Others |
Language: | English Chinese |
Published: |
2012
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Subjects: | |
Online Access: | http://library.cuhk.edu.hk/record=b5549059 http://repository.lib.cuhk.edu.hk/en/item/cuhk-328548 |
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