| Summary: | This research investigated the relationship between exercise training and
cathepsin B expression in the 3xTg-AD murine model of Alzheimer’s disease. 3xTg-AD
mice were assigned to control (Tg, n=10), aerobic training (Tg+AT, n=10), or resistance
training (Tg+RT, n=10). RotaRod peak latency and grip strength were assessed as preand
post-measurements. Skeletal muscle was collected after training and analyzed for
cathepsin B protein. Tg+RT showed greater grip strength than Tg and Tg+AT at posttesting
(p ≤ 0.05). Only Tg+AT showed an improvement in RotaRod peak latency (p ≤
0.05). Gastrocnemius weight was greater in Tg+RT compared to Tg (p ≤ 0.05), and no
differences were observed in cathepsin B or procathepsin B expression (p > 0.05). This
data suggests that cathepsin B was not induced by either mode of exercise training,
however, physical function and muscle mass were improved, therefore inclusion of both
training modalities may address peripheral comorbidities in Alzheimer’s disease. === Includes bibliography. === Thesis (M.S.)--Florida Atlantic University, 2018. === FAU Electronic Theses and Dissertations Collection
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