Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies

Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies

The human genome encodes information that instructs human development, physiology, medicine, and evolution. Massive amount of genomic data has generated an ever-growing pool of hypothesis. Genome editing, broadly defined as targeted changes to the genome, posits to deliver the promise of genomic rev...

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Bibliographic Details
Main Author: Yang, Luhan
Other Authors: Church, George McDonald
Language:en_US
Published: Harvard University 2013
Subjects:
Biomedical engineering
Biochemistry
CRISPR/cas
gene therapy
human genome engineering
TALE
targeted nucleases
Online Access:http://dissertations.umi.com/gsas.harvard:11117
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181072
id ndltd-harvard.edu-oai-dash.harvard.edu-1-11181072
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spelling ndltd-harvard.edu-oai-dash.harvard.edu-1-111810722015-08-14T15:42:42ZDevelopment of Human Genome Editing Tools for the Study of Genetic Variations and Gene TherapiesYang, LuhanBiomedical engineeringBiochemistryCRISPR/casgene therapyhuman genome engineeringTALEtargeted nucleasesThe human genome encodes information that instructs human development, physiology, medicine, and evolution. Massive amount of genomic data has generated an ever-growing pool of hypothesis. Genome editing, broadly defined as targeted changes to the genome, posits to deliver the promise of genomic revolution to transform basic science and personalized medicine. This thesis aims to contribute to this scientific endeavor with a particular focus on the development of effective human genome engineering tools.Church, George McDonald2013-10-18T02:35:13Z2013-10-1720132013-10-18T02:35:13ZThesis or DissertationYang, Luhan. 2013. Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11117http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181072en_USopenhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAAHarvard University
collection NDLTD
language en_US
sources NDLTD
topic Biomedical engineering
Biochemistry
CRISPR/cas
gene therapy
human genome engineering
TALE
targeted nucleases
spellingShingle Biomedical engineering
Biochemistry
CRISPR/cas
gene therapy
human genome engineering
TALE
targeted nucleases
Yang, Luhan
Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies
description The human genome encodes information that instructs human development, physiology, medicine, and evolution. Massive amount of genomic data has generated an ever-growing pool of hypothesis. Genome editing, broadly defined as targeted changes to the genome, posits to deliver the promise of genomic revolution to transform basic science and personalized medicine. This thesis aims to contribute to this scientific endeavor with a particular focus on the development of effective human genome engineering tools.
author2 Church, George McDonald
author_facet Church, George McDonald
Yang, Luhan
author Yang, Luhan
author_sort Yang, Luhan
title Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies
title_short Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies
title_full Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies
title_fullStr Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies
title_full_unstemmed Development of Human Genome Editing Tools for the Study of Genetic Variations and Gene Therapies
title_sort development of human genome editing tools for the study of genetic variations and gene therapies
publisher Harvard University
publishDate 2013
url http://dissertations.umi.com/gsas.harvard:11117
http://nrs.harvard.edu/urn-3:HUL.InstRepos:11181072
work_keys_str_mv AT yangluhan developmentofhumangenomeeditingtoolsforthestudyofgeneticvariationsandgenetherapies
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