Integrative Characterization of Human Long Non-Coding RNAs

Integrative Characterization of Human Long Non-Coding RNAs

Since its early discovery as a messenger, RNA has been shown to play a diverse set of regulatory, structural and even catalytic roles. The more recent understanding that the genome is pervasively transcribed stimulated the discovery of a new prevalent class of long non coding RNAs (lncRNAs). While t...

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Bibliographic Details
Main Author: Cabili, Nataly Moran
Other Authors: Rinn, John L
Language:en_US
Published: Harvard University 2014
Subjects:
Systematic biology
Bioinformatics
Biology
lincRNA
lncRNA
long noncoding-RNA
Online Access:http://dissertations.umi.com/gsas.harvard:11409
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274274
Description
Summary:Since its early discovery as a messenger, RNA has been shown to play a diverse set of regulatory, structural and even catalytic roles. The more recent understanding that the genome is pervasively transcribed stimulated the discovery of a new prevalent class of long non coding RNAs (lncRNAs). While these are lower abundant and relatively less conserved than other class of functional RNAs, lncRNAs are emerging as key players in different cellular processes in development and disease.

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