Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides

Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides

Natural killer (NK) cells can kill virus-infected cells without prior antigenic exposure, and are therefore important for controlling viral replication prior to the onset of adaptive immune responses. Primate NK cells express activating and inhibitory killer-cell immunoglobulin-like receptors (KIRs)...

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Bibliographic Details
Main Author: Schafer, Jamie Lynn
Other Authors: Evans, David
Language:en_US
Published: Harvard University 2014
Subjects:
Virology
Immunology
KIR
MHC class I
NK cell
Rhesus macaque
SIV
Online Access:http://dissertations.umi.com/gsas.harvard:11683
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274520
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spelling ndltd-harvard.edu-oai-dash.harvard.edu-1-122745202015-08-14T15:43:13ZRhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptidesSchafer, Jamie LynnVirologyImmunologyKIRMHC class INK cellRhesus macaqueSIVNatural killer (NK) cells can kill virus-infected cells without prior antigenic exposure, and are therefore important for controlling viral replication prior to the onset of adaptive immune responses. Primate NK cells express activating and inhibitory killer-cell immunoglobulin-like receptors (KIRs) that bind to specific major histocompatibility complex (MHC) class I molecules. The importance of KIR interactions with MHC class I in human immunodeficiency virus (HIV) pathogenesis is demonstrated by the association of select KIR and MHC class I genotypes with delayed progression to acquired immunodeficiency syndrome (AIDS).Evans, David2014-06-06T20:22:55Z2014-06-0620142015-06-04T07:30:49ZThesis or DissertationSchafer, Jamie Lynn. 2014. Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides. Doctoral dissertation, Harvard University.http://dissertations.umi.com/gsas.harvard:11683http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274520en_USopenhttp://nrs.harvard.edu/urn-3:HUL.InstRepos:dash.current.terms-of-use#LAAHarvard University
collection NDLTD
language en_US
sources NDLTD
topic Virology
Immunology
KIR
MHC class I
NK cell
Rhesus macaque
SIV
spellingShingle Virology
Immunology
KIR
MHC class I
NK cell
Rhesus macaque
SIV
Schafer, Jamie Lynn
Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides
description Natural killer (NK) cells can kill virus-infected cells without prior antigenic exposure, and are therefore important for controlling viral replication prior to the onset of adaptive immune responses. Primate NK cells express activating and inhibitory killer-cell immunoglobulin-like receptors (KIRs) that bind to specific major histocompatibility complex (MHC) class I molecules. The importance of KIR interactions with MHC class I in human immunodeficiency virus (HIV) pathogenesis is demonstrated by the association of select KIR and MHC class I genotypes with delayed progression to acquired immunodeficiency syndrome (AIDS).
author2 Evans, David
author_facet Evans, David
Schafer, Jamie Lynn
author Schafer, Jamie Lynn
author_sort Schafer, Jamie Lynn
title Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides
title_short Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides
title_full Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides
title_fullStr Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides
title_full_unstemmed Rhesus macaque KIR recognition of MHC class I molecules: Ligand identification and modulation of interaction by SIV peptides
title_sort rhesus macaque kir recognition of mhc class i molecules: ligand identification and modulation of interaction by siv peptides
publisher Harvard University
publishDate 2014
url http://dissertations.umi.com/gsas.harvard:11683
http://nrs.harvard.edu/urn-3:HUL.InstRepos:12274520
work_keys_str_mv AT schaferjamielynn rhesusmacaquekirrecognitionofmhcclassimoleculesligandidentificationandmodulationofinteractionbysivpeptides
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