The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination
Includes bibliographical references (leaves 102-114). === Bacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem. BCG is administered at birth; however, more than 15% of infants are...
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ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-103772020-10-06T05:11:36Z The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination Dube, Frederick Hanekom, Willem A Medicine Includes bibliographical references (leaves 102-114). Bacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem. BCG is administered at birth; however, more than 15% of infants are born preterm [PT (<37 weeks gestation)], or have low birth weights [LBW (<2,500g)], with >90% of these born in developing countries, where the majority of TB cases are found. It is not known how birth weight at the time of vaccination may affect the BCG-induced immune response and subsequent protection against TB. We hypothesised that BCG-vaccinated PT and LBW infants would have a qualitatively and quantitatevely less optimal immune response, compared to term or normal birth weight (NBW) infants. 2014-12-28T14:55:44Z 2014-12-28T14:55:44Z 2010 Master Thesis Masters MSc http://hdl.handle.net/11427/10377 eng application/pdf University of Cape Town Faculty of Health Sciences Department of Paediatrics and Child Health |
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English |
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Dissertation |
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Medicine |
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Medicine Dube, Frederick The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
description |
Includes bibliographical references (leaves 102-114). === Bacillus Calmette?Gu?rin (BCG), the only currently licensed tuberculosis (TB) vaccine, provides variable efficacy. Despite the use of BCG, TB remains a global health problem. BCG is administered at birth; however, more than 15% of infants are born preterm [PT (<37 weeks gestation)], or have low birth weights [LBW (<2,500g)], with >90% of these born in developing countries, where the majority of TB cases are found. It is not known how birth weight at the time of vaccination may affect the BCG-induced immune response and subsequent protection against TB. We hypothesised that BCG-vaccinated PT and LBW infants would have a qualitatively and quantitatevely less optimal immune response, compared to term or normal birth weight (NBW) infants. |
author2 |
Hanekom, Willem A |
author_facet |
Hanekom, Willem A Dube, Frederick |
author |
Dube, Frederick |
author_sort |
Dube, Frederick |
title |
The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
title_short |
The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
title_full |
The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
title_fullStr |
The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
title_full_unstemmed |
The effect of birth weight and gestational age on BCG-induced immune responses in infants following BCG vaccination |
title_sort |
effect of birth weight and gestational age on bcg-induced immune responses in infants following bcg vaccination |
publisher |
University of Cape Town |
publishDate |
2014 |
url |
http://hdl.handle.net/11427/10377 |
work_keys_str_mv |
AT dubefrederick theeffectofbirthweightandgestationalageonbcginducedimmuneresponsesininfantsfollowingbcgvaccination AT dubefrederick effectofbirthweightandgestationalageonbcginducedimmuneresponsesininfantsfollowingbcgvaccination |
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