Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
Aims of the study: To document the incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of...
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2014
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Online Access: | http://hdl.handle.net/11427/10587 |
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ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-105872020-10-06T05:10:49Z Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients Harris, Tashneem Otorhinolaryngology Aims of the study: To document the incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of MDR-TB patients; To determine whether HIV positive MDR-TB patients are more likely to develop aminoglycoside-induced hearing loss than HIV negative MDR-TB patients; To provide clinical guidelines to the medical fraternity on the use of aminoglycoside antibiotics with regard to the side-effect of ototoxicity. 2014-12-30T19:40:20Z 2014-12-30T19:40:20Z 2011 Master Thesis Masters MMed http://hdl.handle.net/11427/10587 eng application/pdf University of Cape Town Faculty of Health Sciences Division of Otorhinolaryngology |
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NDLTD |
language |
English |
format |
Dissertation |
sources |
NDLTD |
topic |
Otorhinolaryngology |
spellingShingle |
Otorhinolaryngology Harris, Tashneem Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
description |
Aims of the study: To document the incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of MDR-TB patients; To determine whether HIV positive MDR-TB patients are more likely to develop aminoglycoside-induced hearing loss than HIV negative MDR-TB patients; To provide clinical guidelines to the medical fraternity on the use of aminoglycoside antibiotics with regard to the side-effect of ototoxicity. |
author |
Harris, Tashneem |
author_facet |
Harris, Tashneem |
author_sort |
Harris, Tashneem |
title |
Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
title_short |
Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
title_full |
Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
title_fullStr |
Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
title_full_unstemmed |
Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients |
title_sort |
incidence of aminoglycoside-induced hearing loss in hiv positive and hiv negative multidrug-resistant tuberculosis patients |
publisher |
University of Cape Town |
publishDate |
2014 |
url |
http://hdl.handle.net/11427/10587 |
work_keys_str_mv |
AT harristashneem incidenceofaminoglycosideinducedhearinglossinhivpositiveandhivnegativemultidrugresistanttuberculosispatients |
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