Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients

Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients

Aims of the study: To document the incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of...

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Main Author: Harris, Tashneem
Format: Dissertation
Language:English
Published: University of Cape Town 2014
Subjects:
Otorhinolaryngology
Online Access:http://hdl.handle.net/11427/10587
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-105872020-10-06T05:10:49Z Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients Harris, Tashneem Otorhinolaryngology Aims of the study: To document the incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of MDR-TB patients; To determine whether HIV positive MDR-TB patients are more likely to develop aminoglycoside-induced hearing loss than HIV negative MDR-TB patients; To provide clinical guidelines to the medical fraternity on the use of aminoglycoside antibiotics with regard to the side-effect of ototoxicity. 2014-12-30T19:40:20Z 2014-12-30T19:40:20Z 2011 Master Thesis Masters MMed http://hdl.handle.net/11427/10587 eng application/pdf University of Cape Town Faculty of Health Sciences Division of Otorhinolaryngology
collection NDLTD
language English
format Dissertation
sources NDLTD
topic Otorhinolaryngology
spellingShingle Otorhinolaryngology
Harris, Tashneem
Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
description Aims of the study: To document the incidence and severity of aminoglycoside-induced ototoxicity at Brooklyn Chest Hospital; To determine the prevalence of the 6 known aminoglycoside-induced deafness mutations in the MT-RNR1 gene (A1555G, C1494T, T1095C, T1291C, A827G and 961 indel C) in a cohort of MDR-TB patients; To determine whether HIV positive MDR-TB patients are more likely to develop aminoglycoside-induced hearing loss than HIV negative MDR-TB patients; To provide clinical guidelines to the medical fraternity on the use of aminoglycoside antibiotics with regard to the side-effect of ototoxicity.
author Harris, Tashneem
author_facet Harris, Tashneem
author_sort Harris, Tashneem
title Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
title_short Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
title_full Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
title_fullStr Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
title_full_unstemmed Incidence of aminoglycoside-induced hearing loss in HIV positive and HIV negative multidrug-resistant tuberculosis patients
title_sort incidence of aminoglycoside-induced hearing loss in hiv positive and hiv negative multidrug-resistant tuberculosis patients
publisher University of Cape Town
publishDate 2014
url http://hdl.handle.net/11427/10587
work_keys_str_mv AT harristashneem incidenceofaminoglycosideinducedhearinglossinhivpositiveandhivnegativemultidrugresistanttuberculosispatients
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