Corpus callosum morphology in children on mid-sagittal MR imaging

Background: There is little published research on the wide variation of corpus callosum (CC) morphology in children, the assessment of which is made difficult by the complex alteration of its appearance in childhood. Objective: The purpose of our study was to assess the morphology of the CC on mid-s...

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Main Author: Raubenheimer, Lauren
Other Authors: Andronikou, Savvas
Format: Dissertation
Language:English
Published: University of Cape Town 2019
Subjects:
Online Access:http://hdl.handle.net/11427/29692
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-296922020-10-06T05:11:33Z Corpus callosum morphology in children on mid-sagittal MR imaging Raubenheimer, Lauren Andronikou, Savvas Kilborn,Tracy Diagnostic Radiology Background: There is little published research on the wide variation of corpus callosum (CC) morphology in children, the assessment of which is made difficult by the complex alteration of its appearance in childhood. Objective: The purpose of our study was to assess the morphology of the CC on mid-sagittal T1- weighted magnetic resonance imaging (MRI) in a large number of children and correlate the findings with demographic and clinical criteria. Materials and methods: We reviewed all brain mid-sagittal T1-weighted MRI’s performed from July to December 2015 and obtained relevant demographic and clinical information from the accompanying report and laboratory system. The CC morphology was analysed by three radiologists and compared using cross tabulation with the chi-square test and ANOVA. Interobserver correlation was assessed using Kappa coefficient of conformance. Results: 257 patients with mean age 72±60 months were included, 142 were male (55%). In abnormal MRI’s the CC was less likely to have an identifiable isthmus and was more likely to be convex, thin and have separation of the fornix insertion (all p<0.01). In young children (< 5 years) the CC was also less likely to have an identifiable isthmus (p=0.01) and was more likely to be convex (p=0.04) but the fornix was more likely to insert normally (p<0.01). Children with tuberous sclerosis had significantly thinner splenia (p=0.02). Conclusion: There is a distinct pathological appearance of the CC. The immature appearance of the corpus callosum can mirror this but is distinguished by normal insertion of the fornix and normal quantitative measurements. Splenial thinning in children with tuberous sclerosis warrants further investigation. 2019-02-19T13:45:26Z 2019-02-19T13:45:26Z 2018 2019-02-19T10:25:46Z Master Thesis Masters MMed http://hdl.handle.net/11427/29692 eng application/pdf University of Cape Town Faculty of Health Sciences Division of Radiology
collection NDLTD
language English
format Dissertation
sources NDLTD
topic Diagnostic Radiology
spellingShingle Diagnostic Radiology
Raubenheimer, Lauren
Corpus callosum morphology in children on mid-sagittal MR imaging
description Background: There is little published research on the wide variation of corpus callosum (CC) morphology in children, the assessment of which is made difficult by the complex alteration of its appearance in childhood. Objective: The purpose of our study was to assess the morphology of the CC on mid-sagittal T1- weighted magnetic resonance imaging (MRI) in a large number of children and correlate the findings with demographic and clinical criteria. Materials and methods: We reviewed all brain mid-sagittal T1-weighted MRI’s performed from July to December 2015 and obtained relevant demographic and clinical information from the accompanying report and laboratory system. The CC morphology was analysed by three radiologists and compared using cross tabulation with the chi-square test and ANOVA. Interobserver correlation was assessed using Kappa coefficient of conformance. Results: 257 patients with mean age 72±60 months were included, 142 were male (55%). In abnormal MRI’s the CC was less likely to have an identifiable isthmus and was more likely to be convex, thin and have separation of the fornix insertion (all p<0.01). In young children (< 5 years) the CC was also less likely to have an identifiable isthmus (p=0.01) and was more likely to be convex (p=0.04) but the fornix was more likely to insert normally (p<0.01). Children with tuberous sclerosis had significantly thinner splenia (p=0.02). Conclusion: There is a distinct pathological appearance of the CC. The immature appearance of the corpus callosum can mirror this but is distinguished by normal insertion of the fornix and normal quantitative measurements. Splenial thinning in children with tuberous sclerosis warrants further investigation.
author2 Andronikou, Savvas
author_facet Andronikou, Savvas
Raubenheimer, Lauren
author Raubenheimer, Lauren
author_sort Raubenheimer, Lauren
title Corpus callosum morphology in children on mid-sagittal MR imaging
title_short Corpus callosum morphology in children on mid-sagittal MR imaging
title_full Corpus callosum morphology in children on mid-sagittal MR imaging
title_fullStr Corpus callosum morphology in children on mid-sagittal MR imaging
title_full_unstemmed Corpus callosum morphology in children on mid-sagittal MR imaging
title_sort corpus callosum morphology in children on mid-sagittal mr imaging
publisher University of Cape Town
publishDate 2019
url http://hdl.handle.net/11427/29692
work_keys_str_mv AT raubenheimerlauren corpuscallosummorphologyinchildrenonmidsagittalmrimaging
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