Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation

Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation

Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-tr...

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Bibliographic Details
Main Author: Centner, Chad
Other Authors: Heckmann, Jeannine
Format: Dissertation
Language:English
Published: University of Cape Town 2014
Subjects:
Medicine
Online Access:http://hdl.handle.net/11427/3370
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-33702020-10-06T05:10:52Z Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation Centner, Chad Heckmann, Jeannine Dandara, Collet Medicine Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-treatment for HIV/TB, DSP risk is increased. Factors driving this risk may be vitamin B6 deficiency and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known risk 2014-07-29T09:02:54Z 2014-07-29T09:02:54Z 2012 Master Thesis Masters MMed http://hdl.handle.net/11427/3370 eng application/pdf University of Cape Town Faculty of Health Sciences Department of Medicine
collection NDLTD
language English
format Dissertation
sources NDLTD
topic Medicine
spellingShingle Medicine
Centner, Chad
Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
description Both human immunodeficiency virus (HIV) infection and tuberculosis (TB) are complicated by a painful distal sensory polyneuropathy (DSP) that may be due to virus-related HIV-DSP, antiretroviral toxic neuropathy (ATN) or isoniazid-induced peripheral neuropathy (INH-PN). In co-infection with and co-treatment for HIV/TB, DSP risk is increased. Factors driving this risk may be vitamin B6 deficiency and slow metabolism of INH mediated by N-acetyltransferase 2 (NAT2) acetylation, both known risk
author2 Heckmann, Jeannine
author_facet Heckmann, Jeannine
Centner, Chad
author Centner, Chad
author_sort Centner, Chad
title Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
title_short Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
title_full Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
title_fullStr Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
title_full_unstemmed Distal sensory polyneuropathy in HIV/TB co-infection : the role of vitamin B6 and N-acetyltransferase 2 genetic variation
title_sort distal sensory polyneuropathy in hiv/tb co-infection : the role of vitamin b6 and n-acetyltransferase 2 genetic variation
publisher University of Cape Town
publishDate 2014
url http://hdl.handle.net/11427/3370
work_keys_str_mv AT centnerchad distalsensorypolyneuropathyinhivtbcoinfectiontheroleofvitaminb6andnacetyltransferase2geneticvariation
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