Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents
Includes bibliographical references. === Includes bibliographical references. === Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat...
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Online Access: | http://hdl.handle.net/11427/6283 |
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ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-62832020-10-07T05:11:30Z Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents Watermeyer, Nicholas D Chibale, Kelly Chemistry Includes bibliographical references. Includes bibliographical references. Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat the disease has been significantly hindered. Future research into the synthesis of new 4-aminoquinoline derivatives is warranted, since it has been found that the resistance is based on the identity of the side chain and not on the aminoquinoline ring, the functionality by which these compounds derive their activity. Consequently, the synthesis of CO derivatives with a modified side chain attached to a substituted quinoline ring is a reasonable approach in the search of novel antimalarial compounds that are active against drug-resistant parasite strains. 2014-08-13T14:25:31Z 2014-08-13T14:25:31Z 2008 Master Thesis Masters MSc http://hdl.handle.net/11427/6283 eng application/pdf University of Cape Town Faculty of Science Department of Chemistry |
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English |
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Dissertation |
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Chemistry |
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Chemistry Watermeyer, Nicholas D Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
description |
Includes bibliographical references. === Includes bibliographical references. === Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat the disease has been significantly hindered. Future research into the synthesis of new 4-aminoquinoline derivatives is warranted, since it has been found that the resistance is based on the identity of the side chain and not on the aminoquinoline ring, the functionality by which these compounds derive their activity. Consequently, the synthesis of CO derivatives with a modified side chain attached to a substituted quinoline ring is a reasonable approach in the search of novel antimalarial compounds that are active against drug-resistant parasite strains. |
author2 |
Chibale, Kelly |
author_facet |
Chibale, Kelly Watermeyer, Nicholas D |
author |
Watermeyer, Nicholas D |
author_sort |
Watermeyer, Nicholas D |
title |
Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
title_short |
Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
title_full |
Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
title_fullStr |
Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
title_full_unstemmed |
Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
title_sort |
bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents |
publisher |
University of Cape Town |
publishDate |
2014 |
url |
http://hdl.handle.net/11427/6283 |
work_keys_str_mv |
AT watermeyernicholasd bioactivechloroquinebasedligandsandtheirgoldcomplexesaspotentialnovelantimalarialagents |
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1719350970986528768 |