Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents

Includes bibliographical references. === Includes bibliographical references. === Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat...

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Main Author: Watermeyer, Nicholas D
Other Authors: Chibale, Kelly
Format: Dissertation
Language:English
Published: University of Cape Town 2014
Subjects:
Online Access:http://hdl.handle.net/11427/6283
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-62832020-10-07T05:11:30Z Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents Watermeyer, Nicholas D Chibale, Kelly Chemistry Includes bibliographical references. Includes bibliographical references. Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat the disease has been significantly hindered. Future research into the synthesis of new 4-aminoquinoline derivatives is warranted, since it has been found that the resistance is based on the identity of the side chain and not on the aminoquinoline ring, the functionality by which these compounds derive their activity. Consequently, the synthesis of CO derivatives with a modified side chain attached to a substituted quinoline ring is a reasonable approach in the search of novel antimalarial compounds that are active against drug-resistant parasite strains. 2014-08-13T14:25:31Z 2014-08-13T14:25:31Z 2008 Master Thesis Masters MSc http://hdl.handle.net/11427/6283 eng application/pdf University of Cape Town Faculty of Science Department of Chemistry
collection NDLTD
language English
format Dissertation
sources NDLTD
topic Chemistry
spellingShingle Chemistry
Watermeyer, Nicholas D
Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents
description Includes bibliographical references. === Includes bibliographical references. === Chloroquine(CO)-derived 4-aminoquinolines have proven to be the most efficacious antimalarial drugs for both the treatment and prophylaxis of malaria. However, with the advent of drug resistance, their ability to treat the disease has been significantly hindered. Future research into the synthesis of new 4-aminoquinoline derivatives is warranted, since it has been found that the resistance is based on the identity of the side chain and not on the aminoquinoline ring, the functionality by which these compounds derive their activity. Consequently, the synthesis of CO derivatives with a modified side chain attached to a substituted quinoline ring is a reasonable approach in the search of novel antimalarial compounds that are active against drug-resistant parasite strains.
author2 Chibale, Kelly
author_facet Chibale, Kelly
Watermeyer, Nicholas D
author Watermeyer, Nicholas D
author_sort Watermeyer, Nicholas D
title Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents
title_short Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents
title_full Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents
title_fullStr Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents
title_full_unstemmed Bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents
title_sort bioactive chloroquine-based ligands and their gold complexes as potential novel antimalarial agents
publisher University of Cape Town
publishDate 2014
url http://hdl.handle.net/11427/6283
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