Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery
Bibliography: leaves 81-83. === Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component a...
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ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-63252020-10-07T05:11:36Z Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery Mabizela, Nontobeko Chibale, Kelly Chemistry Bibliography: leaves 81-83. Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component aza Baylis-Hillman reactions synthesised for biological evaluation as potential inhibitors of two parasitic cysteine proteases (cruzain and Falcipain-2) and as antiparasitic agents. The utilization of polymer-supported bases in the Baylis-Hillman reaction is described. The use of ultrasound in combination with Lewis acids is also described in an attempt to improve the reaction rate. 2014-08-13T14:26:54Z 2014-08-13T14:26:54Z 2003 Master Thesis Masters MSc http://hdl.handle.net/11427/6325 eng application/pdf University of Cape Town Faculty of Science Department of Chemistry |
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English |
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Dissertation |
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Chemistry |
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Chemistry Mabizela, Nontobeko Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
description |
Bibliography: leaves 81-83. === Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component aza Baylis-Hillman reactions synthesised for biological evaluation as potential inhibitors of two parasitic cysteine proteases (cruzain and Falcipain-2) and as antiparasitic agents. The utilization of polymer-supported bases in the Baylis-Hillman reaction is described. The use of ultrasound in combination with Lewis acids is also described in an attempt to improve the reaction rate. |
author2 |
Chibale, Kelly |
author_facet |
Chibale, Kelly Mabizela, Nontobeko |
author |
Mabizela, Nontobeko |
author_sort |
Mabizela, Nontobeko |
title |
Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
title_short |
Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
title_full |
Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
title_fullStr |
Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
title_full_unstemmed |
Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery |
title_sort |
utilization of the baylis-hillman and related reactions in antiparasitic drug discovery |
publisher |
University of Cape Town |
publishDate |
2014 |
url |
http://hdl.handle.net/11427/6325 |
work_keys_str_mv |
AT mabizelanontobeko utilizationofthebaylishillmanandrelatedreactionsinantiparasiticdrugdiscovery |
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1719351478284451840 |