Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery

Bibliography: leaves 81-83. === Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component a...

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Main Author: Mabizela, Nontobeko
Other Authors: Chibale, Kelly
Format: Dissertation
Language:English
Published: University of Cape Town 2014
Subjects:
Online Access:http://hdl.handle.net/11427/6325
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spelling ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-63252020-10-07T05:11:36Z Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery Mabizela, Nontobeko Chibale, Kelly Chemistry Bibliography: leaves 81-83. Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component aza Baylis-Hillman reactions synthesised for biological evaluation as potential inhibitors of two parasitic cysteine proteases (cruzain and Falcipain-2) and as antiparasitic agents. The utilization of polymer-supported bases in the Baylis-Hillman reaction is described. The use of ultrasound in combination with Lewis acids is also described in an attempt to improve the reaction rate. 2014-08-13T14:26:54Z 2014-08-13T14:26:54Z 2003 Master Thesis Masters MSc http://hdl.handle.net/11427/6325 eng application/pdf University of Cape Town Faculty of Science Department of Chemistry
collection NDLTD
language English
format Dissertation
sources NDLTD
topic Chemistry
spellingShingle Chemistry
Mabizela, Nontobeko
Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery
description Bibliography: leaves 81-83. === Baylis-Hillman adducts and compounds containing quinoline moieties have been previously utilized extensively in the search for antiparasitic agents. Work in this dissertation describes a series of compounds based on the Baylis-Hillman and the related three-component aza Baylis-Hillman reactions synthesised for biological evaluation as potential inhibitors of two parasitic cysteine proteases (cruzain and Falcipain-2) and as antiparasitic agents. The utilization of polymer-supported bases in the Baylis-Hillman reaction is described. The use of ultrasound in combination with Lewis acids is also described in an attempt to improve the reaction rate.
author2 Chibale, Kelly
author_facet Chibale, Kelly
Mabizela, Nontobeko
author Mabizela, Nontobeko
author_sort Mabizela, Nontobeko
title Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery
title_short Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery
title_full Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery
title_fullStr Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery
title_full_unstemmed Utilization of the Baylis-Hillman and related reactions in antiparasitic drug discovery
title_sort utilization of the baylis-hillman and related reactions in antiparasitic drug discovery
publisher University of Cape Town
publishDate 2014
url http://hdl.handle.net/11427/6325
work_keys_str_mv AT mabizelanontobeko utilizationofthebaylishillmanandrelatedreactionsinantiparasiticdrugdiscovery
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