Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques

Includes abstract. === Includes bibliographical references. === The need to come up with new and novel antibiotics that utilize unique mechanisms, to which bacteria cannot generate resistance, was the main motivation of this study. Tyrocidine peptides are non-selective antibiotics that have such pro...

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Bibliographic Details
Main Author:	Munyuki, Gadzikano
Other Authors:	Jackson, Graham Ellis
Format:	Doctoral Thesis
Language:	English
Published:	University of Cape Town 2014
Subjects:	Chemistry
Online Access:	http://hdl.handle.net/11427/6347

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spelling	ndltd-netd.ac.za-oai-union.ndltd.org-uct-oai-localhost-11427-63472020-07-22T05:07:26Z Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques Munyuki, Gadzikano Jackson, Graham Ellis Venter, Gerhard Chemistry Includes abstract. Includes bibliographical references. The need to come up with new and novel antibiotics that utilize unique mechanisms, to which bacteria cannot generate resistance, was the main motivation of this study. Tyrocidine peptides are non-selective antibiotics that have such properties. However, very limited information is available about their mechanism of action. The aim of this study was to determine the mechanism of action of tyrocidine peptides, tyrocidine A, tyrocidine B and tyrocidine C. 2014-08-13T14:27:33Z 2014-08-13T14:27:33Z 2012 Doctoral Thesis Doctoral PhD http://hdl.handle.net/11427/6347 eng application/pdf University of Cape Town Faculty of Science Department of Chemistry
collection	NDLTD
language	English
format	Doctoral Thesis
sources	NDLTD
topic	Chemistry
spellingShingle	Chemistry Munyuki, Gadzikano Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques
description	Includes abstract. === Includes bibliographical references. === The need to come up with new and novel antibiotics that utilize unique mechanisms, to which bacteria cannot generate resistance, was the main motivation of this study. Tyrocidine peptides are non-selective antibiotics that have such properties. However, very limited information is available about their mechanism of action. The aim of this study was to determine the mechanism of action of tyrocidine peptides, tyrocidine A, tyrocidine B and tyrocidine C.
author2	Jackson, Graham Ellis
author_facet	Jackson, Graham Ellis Munyuki, Gadzikano
author	Munyuki, Gadzikano
author_sort	Munyuki, Gadzikano
title	Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques
title_short	Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques
title_full	Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques
title_fullStr	Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques
title_full_unstemmed	Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques
title_sort	molecular mechanism of action of tyrocidine antimicrobial peptides using nmr spectroscopy and computational techniques
publisher	University of Cape Town
publishDate	2014
url	http://hdl.handle.net/11427/6347
work_keys_str_mv	AT munyukigadzikano molecularmechanismofactionoftyrocidineantimicrobialpeptidesusingnmrspectroscopyandcomputationaltechniques
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Molecular mechanism of action of tyrocidine antimicrobial peptides using NMR spectroscopy and computational techniques

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