| Summary: | Background: IPT is an effective, safe and feasible disease prevention scheme that should
be administered for all PLHIV living in areas with high latent TB prevalence.
Objective: To assess the impact of isoniazid in the incidence of tuberculosis among HIV
infected individuals in Addis Ababa.
Methods: A case control study design was undertaken among 489 HIV and TB infected
patients in Addis Ababa from January 2008 to December 2010.
Results: Tuberculosis incidence rate among those who developed TB after completing 6-9
month isoniazid preventative therapy was17.14 PYO compared to 10.28 PYO among
those who were not. Isonizide reduced the chance of developing tuberculosis among HIV
infected patients (OR= 0.072; 95% CI 0.044, 0.12). Age (AOR= 0.14; 95% CI 0.03, 0.97)
and sex (AOR= 1.86; 95% CI 1.02, 2.23) of the patient, CD4 count at HIV diagnosis
(AOR= 0.21; 95% CI 0.13, 0.31), clinical stage of HIV illness (AOR= 1.22; 95% CI 1.09,
1.84) and past tuberculosis history (AOR = 1.97; 95% CI 1.24, 3.67) were major factors
associated with tuberculosis incidence.
Conclusions: INH prophylaxis was associated with lower incidence of tuberculosis among
PLHIV. === Health Studies === M. Public Health
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