An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.

An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.

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<p> <p>&nbsp === </p> </p> <p align="left">Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa human splicing-associated protein that is also known to interact with tumour suppressor proteins p53 and pRb and to mediate ubiquitination of p53 via its inter...

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Bibliographic Details
Main Author: Mulaudzi, Takalani.
Format: Others
Language:English
Published: 2007
Subjects:
15N-HSQC
1H-113Cd-HSQC
Cadmium ion
Coordination
Expression
RING
Spectroscopy
Zinc ion.
Online Access:http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9063_1260173635
id ndltd-netd.ac.za-oai-union.ndltd.org-uwc-oai-UWC_ETD-http%3A%2F%2Fetd.uwc.ac.za%2Findex.php%3Fmodule%3Detd%26action%3Dviewtitle%26id%3Dgen8Srv25Nme4_9063_1260173635
record_format oai_dc
spelling ndltd-netd.ac.za-oai-union.ndltd.org-uwc-oai-UWC_ETD-http%3A%2F%2Fetd.uwc.ac.za%2Findex.php%3Fmodule%3Detd%26action%3Dviewtitle%26id%3Dgen8Srv25Nme4_9063_12601736352014-02-08T03:47:49Z An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy. Mulaudzi, Takalani. 15N-HSQC 1H-113Cd-HSQC Cadmium ion Coordination Expression RING Spectroscopy Zinc ion. <p> <p>&nbsp </p> </p> <p align="left">Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa human splicing-associated protein that is also known to interact with tumour suppressor proteins p53 and pRb and to mediate ubiquitination of p53 via its interaction with Hdm2. RBBP6 is highly up regulated in oesophageal cancer, and has been shown to be a promising target for immunotherapy against the disease. RBBP6 is also known to play a role in mRNA splicing, cell cycle control and apoptosis.</p> 2007 Thesis and dissertation Pdf http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9063_1260173635 English ZA Copyright: University of the Western Cape
collection NDLTD
language English
format Others
sources NDLTD
topic 15N-HSQC
1H-113Cd-HSQC
Cadmium ion
Coordination
Expression
RING
Spectroscopy
Zinc ion.
spellingShingle 15N-HSQC
1H-113Cd-HSQC
Cadmium ion
Coordination
Expression
RING
Spectroscopy
Zinc ion.
Mulaudzi, Takalani.
An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.
description <p> <p>&nbsp === </p> </p> <p align="left">Retinoblastoma binding protein 6 (RBBP6) is a 250 kDa human splicing-associated protein that is also known to interact with tumour suppressor proteins p53 and pRb and to mediate ubiquitination of p53 via its interaction with Hdm2. RBBP6 is highly up regulated in oesophageal cancer, and has been shown to be a promising target for immunotherapy against the disease. RBBP6 is also known to play a role in mRNA splicing, cell cycle control and apoptosis.</p>
author Mulaudzi, Takalani.
author_facet Mulaudzi, Takalani.
author_sort Mulaudzi, Takalani.
title An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.
title_short An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.
title_full An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.
title_fullStr An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.
title_full_unstemmed An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.
title_sort investigation of the zinc binding characteristics of the ring finger domain from the human rbbp6 protein using heteronuclear nmr spectroscopy.
publishDate 2007
url http://etd.uwc.ac.za/index.php?module=etd&action=viewtitle&id=gen8Srv25Nme4_9063_1260173635
work_keys_str_mv AT mulaudzitakalani aninvestigationofthezincbindingcharacteristicsoftheringfingerdomainfromthehumanrbbp6proteinusingheteronuclearnmrspectroscopy
AT mulaudzitakalani investigationofthezincbindingcharacteristicsoftheringfingerdomainfromthehumanrbbp6proteinusingheteronuclearnmrspectroscopy
_version_ 1716634502617366528

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