An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.

An investigation of the zinc binding characteristics of the RING finger domain from the human RBBP6 protein using heteronuclear NMR spectroscopy.

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Magister Scientiae - MSc === Retinoblastoma binding prot ein 6 (RBBP6) is a 250 kDa human splicing-associated protein that is also known to interact with tumour suppresso r proteins p53 and pRb and to mediate ubiquitination of p53 via its intera ction with Hdm2. RBBP6 is highly up regulated i...

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Bibliographic Details
Main Author: Mulaudzi, Takalani
Other Authors: Pugh, David J.R.
Language:en
Published: University of the Western Cape 2014
Subjects:
15N-HSQC
1H-113Cd-HSQC
Cadmium ion
Coordination
Expression
RING
Spectroscopy
Zinc ion
Online Access:http://hdl.handle.net/11394/2833
Description
Summary:Magister Scientiae - MSc === Retinoblastoma binding prot ein 6 (RBBP6) is a 250 kDa human splicing-associated protein that is also known to interact with tumour suppresso r proteins p53 and pRb and to mediate ubiquitination of p53 via its intera ction with Hdm2. RBBP6 is highly up regulated in oesophageal cancer, and has been shown to be a promising target for immunotherapy against the disease. RBBP6 is also known to play a role in mRNA splicing, cell cycle control and apoptosis. === South Africa

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