The Generation of Antibodies against Human Coronavirus NL63 (HCoV-NL63) Nucleocapsid Protein
Magister Scientiae - MSc (Medical BioSciences) === Coronaviruses (CoVs) are enveloped viruses composed of single-stranded, positive sense RNA viruses with the largest viral genomes among RNA viruses (27-33 kb). In 2004, human coronavirus NL63 (HCoV-NL63) was discovered by researchers from The Nether...
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ndltd-netd.ac.za-oai-union.ndltd.org-uwc-oai-etd.uwc.ac.za-11394-61112018-09-02T08:03:34Z The Generation of Antibodies against Human Coronavirus NL63 (HCoV-NL63) Nucleocapsid Protein Smith, Marjorie Fielding, B.C Magister Scientiae - MSc (Medical BioSciences) Coronaviruses (CoVs) are enveloped viruses composed of single-stranded, positive sense RNA viruses with the largest viral genomes among RNA viruses (27-33 kb). In 2004, human coronavirus NL63 (HCoV-NL63) was discovered by researchers from The Netherlands. Since its discovery, it has been found in countries all over the world and affects mainly young children between ages 0-5 years old, immunocompromised and elderly people. HCoV-NL63 has been indicated to cause both mild upper and more serious, but less common, lower respiratory tract infections and are commonly associated with other respiratory viruses in co-infections that can increase the severity of HCoV-NL63 infection. The nucleocapsid (N) protein of HCoV-NL63 is a multifunctional phosphoprotein that modulates the assembly of the ribonucleocapsid core of mature virions. During infection, the N protein is expressed at high levels within an infected cell and elicits a strong immune response in infected patients. For this reason, N protein was used to generate antibodies against an immune response to the presence of HCoV-NL63 N protein in mouse blood serum. 2018-07-25T10:47:18Z 2018-08-31T22:10:06Z 2017 http://hdl.handle.net/11394/6111 en University of the Western Cape University of the Western Cape |
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Magister Scientiae - MSc (Medical BioSciences) === Coronaviruses (CoVs) are enveloped viruses composed of single-stranded, positive sense
RNA viruses with the largest viral genomes among RNA viruses (27-33 kb). In 2004,
human coronavirus NL63 (HCoV-NL63) was discovered by researchers from The
Netherlands. Since its discovery, it has been found in countries all over the world and affects mainly
young children between ages 0-5 years old, immunocompromised and elderly people.
HCoV-NL63 has been indicated to cause both mild upper and more serious, but less
common, lower respiratory tract infections and are commonly associated with other
respiratory viruses in co-infections that can increase the severity of HCoV-NL63
infection. The nucleocapsid (N) protein of HCoV-NL63 is a multifunctional
phosphoprotein that modulates the assembly of the ribonucleocapsid core of mature
virions. During infection, the N protein is expressed at high levels within an infected cell
and elicits a strong immune response in infected patients. For this reason, N protein was
used to generate antibodies against an immune response to the presence of HCoV-NL63
N protein in mouse blood serum. |
author2 |
Fielding, B.C |
author_facet |
Fielding, B.C Smith, Marjorie |
author |
Smith, Marjorie |
spellingShingle |
Smith, Marjorie The Generation of Antibodies against Human Coronavirus NL63 (HCoV-NL63) Nucleocapsid Protein |
author_sort |
Smith, Marjorie |
title |
The Generation of Antibodies against Human
Coronavirus NL63 (HCoV-NL63) Nucleocapsid
Protein |
title_short |
The Generation of Antibodies against Human
Coronavirus NL63 (HCoV-NL63) Nucleocapsid
Protein |
title_full |
The Generation of Antibodies against Human
Coronavirus NL63 (HCoV-NL63) Nucleocapsid
Protein |
title_fullStr |
The Generation of Antibodies against Human
Coronavirus NL63 (HCoV-NL63) Nucleocapsid
Protein |
title_full_unstemmed |
The Generation of Antibodies against Human
Coronavirus NL63 (HCoV-NL63) Nucleocapsid
Protein |
title_sort |
generation of antibodies against human
coronavirus nl63 (hcov-nl63) nucleocapsid
protein |
publisher |
University of the Western Cape |
publishDate |
2018 |
url |
http://hdl.handle.net/11394/6111 |
work_keys_str_mv |
AT smithmarjorie thegenerationofantibodiesagainsthumancoronavirusnl63hcovnl63nucleocapsidprotein AT smithmarjorie generationofantibodiesagainsthumancoronavirusnl63hcovnl63nucleocapsidprotein |
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1718728371127451648 |