The preformulation investigation of a combination anti-tuberculosis dosage form

• Main Author: Ebrahim, Salma
• Format: Others
• Language: en
• Published: 2018
• Subjects: Tuberculosis Vaccines; South Africa; Isoniazid; Pyrazinamide; Ethambutol
• Online Access: https://hdl.handle.net/10539/25753

A research report submitted to the Faculty of Health Sciences, University of the Witwatersrand, in partial fulfilment of the requirements for the degree of Master of Science in Medicine (Pharmaceutical affairs) Johannesburg, 1998 === Tuberculosis control in South Africa continues to be a major challenge with 90 000 new cases reported in 1995. Major contributory factors towards these epidemic proportions are patient non-compliance and the occurrence of drug resistant tuberculosis. Fixed drug combinations of anti-tuberculosis drugs have been reported to reduce the possibility of resistance arising to any one of the drugs in combination and to improve compliance. However, the combination anti-tuberculosis drugs available at present still suffer the disadvantage of patients having to take 6 tablets per day. Therefore, the purpose of this project was to investigate a formulation that would reduce this disadvantage. === IT2018