Univerzální využití kapalinové chromatografie a hmotnostní spektrometrie v metabolismu léčiv
Human organism has always been exposed to a vast array of chemicals encountered in the environment. Chemical revolution has significantly influenced biological evolution of humans leading to serious unpredictable toxicities. In response to continual chemical stress they have developed a variety of e...
Main Author: | |
---|---|
Other Authors: | |
Format: | Doctoral Thesis |
Language: | English |
Published: |
2007
|
Online Access: | http://www.nusl.cz/ntk/nusl-271007 |
id |
ndltd-nusl.cz-oai-invenio.nusl.cz-271007 |
---|---|
record_format |
oai_dc |
spelling |
ndltd-nusl.cz-oai-invenio.nusl.cz-2710072018-11-16T04:17:03Z Univerzální využití kapalinové chromatografie a hmotnostní spektrometrie v metabolismu léčiv Versatile use of liquid chromatography and mass spectrometry in drug metabolism studies Suchanová, Bohumila Wsól, Vladimír Solich, Petr Lemr, Karel Human organism has always been exposed to a vast array of chemicals encountered in the environment. Chemical revolution has significantly influenced biological evolution of humans leading to serious unpredictable toxicities. In response to continual chemical stress they have developed a variety of enzymes to transform these xenobiotics. Xenobiotics are mostly highly lipophilic and cannot readily be excreted from the body without metabolism to more hydrophilic, water-soluble metabolites. Not only environmental chemicals represent xenobiotics but also drugs, dietary components etc. Biotransformation studies play an important role in the drug discovery and development process. Usually data from drug metabolism is required before a new substance can advance towards the development stages of a new therapeutic agent. Data on metabolism is frequently used to optimize drug candidates, suggest more active compounds or support toxicology studies. The increased flux of new chemical entities into drug discovery has placed an increased need for fast and reliable information on the metabolism of these substances. Liquid chromatography coupled with mass spectrometry can meet demands for rapid drugs and metabolites analysis imposed by modern drug discovery strategies. This dissertation thesis presents an evidence... 2007 info:eu-repo/semantics/doctoralThesis http://www.nusl.cz/ntk/nusl-271007 eng info:eu-repo/semantics/restrictedAccess |
collection |
NDLTD |
language |
English |
format |
Doctoral Thesis |
sources |
NDLTD |
description |
Human organism has always been exposed to a vast array of chemicals encountered in the environment. Chemical revolution has significantly influenced biological evolution of humans leading to serious unpredictable toxicities. In response to continual chemical stress they have developed a variety of enzymes to transform these xenobiotics. Xenobiotics are mostly highly lipophilic and cannot readily be excreted from the body without metabolism to more hydrophilic, water-soluble metabolites. Not only environmental chemicals represent xenobiotics but also drugs, dietary components etc. Biotransformation studies play an important role in the drug discovery and development process. Usually data from drug metabolism is required before a new substance can advance towards the development stages of a new therapeutic agent. Data on metabolism is frequently used to optimize drug candidates, suggest more active compounds or support toxicology studies. The increased flux of new chemical entities into drug discovery has placed an increased need for fast and reliable information on the metabolism of these substances. Liquid chromatography coupled with mass spectrometry can meet demands for rapid drugs and metabolites analysis imposed by modern drug discovery strategies. This dissertation thesis presents an evidence... |
author2 |
Wsól, Vladimír |
author_facet |
Wsól, Vladimír Suchanová, Bohumila |
author |
Suchanová, Bohumila |
spellingShingle |
Suchanová, Bohumila Univerzální využití kapalinové chromatografie a hmotnostní spektrometrie v metabolismu léčiv |
author_sort |
Suchanová, Bohumila |
title |
Univerzální využití kapalinové chromatografie a hmotnostní spektrometrie v metabolismu léčiv |
title_short |
Univerzální využití kapalinové chromatografie a hmotnostní spektrometrie v metabolismu léčiv |
title_full |
Univerzální využití kapalinové chromatografie a hmotnostní spektrometrie v metabolismu léčiv |
title_fullStr |
Univerzální využití kapalinové chromatografie a hmotnostní spektrometrie v metabolismu léčiv |
title_full_unstemmed |
Univerzální využití kapalinové chromatografie a hmotnostní spektrometrie v metabolismu léčiv |
title_sort |
univerzální využití kapalinové chromatografie a hmotnostní spektrometrie v metabolismu léčiv |
publishDate |
2007 |
url |
http://www.nusl.cz/ntk/nusl-271007 |
work_keys_str_mv |
AT suchanovabohumila univerzalnivyuzitikapalinovechromatografieahmotnostnispektrometrievmetabolismuleciv AT suchanovabohumila versatileuseofliquidchromatographyandmassspectrometryindrugmetabolismstudies |
_version_ |
1718791226341195776 |