Možnosti preemptivní analgézie a zvýšení účinnosti analgetik neurofarmaky

• Main Author: Slíva, Jiří
• Other Authors: Kršiak, Miloslav
• Format: Doctoral Thesis
• Language: Czech
• Published: 2010
• Online Access: http://www.nusl.cz/ntk/nusl-278490

The aim of our research is was to determine whether new and already clinically successfullyused anticonvulsant levetiracetam has a preemptive or therapeutic effects in the model of postoperative pain in rats. The second objective of our research was to determine whether guaifenesin increases the efficiency even analgesic NSAIDs, with different selectivity for COX-2 (ibuprofen, nimesulide and celecoxib) in the model of visceral pain in mice. As Previously, it was discovered that guaifenesin increases theabsorption of paracetamol, we investigated whether guaifenesin also affect plasma levels of one of the NSAIDs tested, andnimesulide. The third main objective of our research was therefore to determine whether cannabinoid receptor agonist CP-55940 increases the analgesic activity of diclofenac in amodel of visceral pain model in mice and inflammatory pain in rat.