Purinové receptory močového měchýře potkana: funkční změny purinergních P1A1 receptorů při zánětu močového měchýře
This project was focused on studies of the location and function of selected purinergic receptors in the rat urinary bladder. Its special concerns are on adenosine P1A1 purinoceptors and on their expression in healthy and inflamed urinary bladders of the rat. It was found that both P2X1 and P1A1 rec...
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| Format: | Dissertation |
| Language: | English |
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2009
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| Online Access: | http://www.nusl.cz/ntk/nusl-279073 |
| Summary: | This project was focused on studies of the location and function of selected purinergic receptors in the rat urinary bladder. Its special concerns are on adenosine P1A1 purinoceptors and on their expression in healthy and inflamed urinary bladders of the rat. It was found that both P2X1 and P1A1 receptors are expressed in urinary bladder. The quantity of P1A1 receptors is decreased in the inflamed bladder. Functional studies based on an agonist stimulation (adenosine) showed importance of P1A1 receptors for relaxation of the tissue. During the cystitis this effect was reduced. Electric field stimulation (EFS) pointed out the difference between the response to a stimulus affecting just postsynaptic receptors (adenosine stimulation) and responses to nerve stimulation including both post- and presynaptic effects. |
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