Analytické hodnocení léčiv s využitím chromatografických metod I

Analytical evaluation of the drugs using chromatographic methods I. (Determination of the conditions for simultaneous evaluation of clotrimazole and benzylalcohol) Thesis Michal Hladík Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Dru...

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Main Author:	Hladík, Michal
Other Authors:	Mokrý, Milan
Format:	Dissertation
Language:	Czech
Published:	2007
Online Access:	http://www.nusl.cz/ntk/nusl-280074

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spelling	ndltd-nusl.cz-oai-invenio.nusl.cz-2800742017-09-02T04:15:35Z Analytické hodnocení léčiv s využitím chromatografických metod I Analytical evaluation of the pharmaceutical formulations using chromatographic methods I Hladík, Michal Mokrý, Milan Kastner, Petr Analytical evaluation of the drugs using chromatographic methods I. (Determination of the conditions for simultaneous evaluation of clotrimazole and benzylalcohol) Thesis Michal Hladík Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Analysis Optimum chromatographic conditions for simultaneous HPLC determination of clotrimazole and benzylacohol in a pharmaceutical formulations (2 % cream) were elaborated. The best results was achieved using chromatographic column Separon SGX CN, 7 μm, 150 x 4 mm I. D. (Tessek Prague, Czech Republic). The mobile phase consisted of mixture of acetonitrile and aqueous solution of K2HPO4 0.05 mol/l (60 : 40), pH 6.7 (adjusted with 10 % H3PO4). The flow rate was 0.8 ml/min. The UV detector set at 268 nm was used. Method was validated for linearity and robustness. Complete validation will be an aim of the next rigorous work. 2007 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-280074 cze info:eu-repo/semantics/restrictedAccess
collection	NDLTD
language	Czech
format	Dissertation
sources	NDLTD
description	Analytical evaluation of the drugs using chromatographic methods I. (Determination of the conditions for simultaneous evaluation of clotrimazole and benzylalcohol) Thesis Michal Hladík Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Pharmaceutical Chemistry and Drug Analysis Optimum chromatographic conditions for simultaneous HPLC determination of clotrimazole and benzylacohol in a pharmaceutical formulations (2 % cream) were elaborated. The best results was achieved using chromatographic column Separon SGX CN, 7 μm, 150 x 4 mm I. D. (Tessek Prague, Czech Republic). The mobile phase consisted of mixture of acetonitrile and aqueous solution of K2HPO4 0.05 mol/l (60 : 40), pH 6.7 (adjusted with 10 % H3PO4). The flow rate was 0.8 ml/min. The UV detector set at 268 nm was used. Method was validated for linearity and robustness. Complete validation will be an aim of the next rigorous work.
author2	Mokrý, Milan
author_facet	Mokrý, Milan Hladík, Michal
author	Hladík, Michal
spellingShingle	Hladík, Michal Analytické hodnocení léčiv s využitím chromatografických metod I
author_sort	Hladík, Michal
title	Analytické hodnocení léčiv s využitím chromatografických metod I
title_short	Analytické hodnocení léčiv s využitím chromatografických metod I
title_full	Analytické hodnocení léčiv s využitím chromatografických metod I
title_fullStr	Analytické hodnocení léčiv s využitím chromatografických metod I
title_full_unstemmed	Analytické hodnocení léčiv s využitím chromatografických metod I
title_sort	analytické hodnocení léčiv s využitím chromatografických metod i
publishDate	2007
url	http://www.nusl.cz/ntk/nusl-280074
work_keys_str_mv	AT hladikmichal analytickehodnocenilecivsvyuzitimchromatografickychmetodi AT hladikmichal analyticalevaluationofthepharmaceuticalformulationsusingchromatographicmethodsi
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Analytické hodnocení léčiv s využitím chromatografických metod I

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