Vztah mezi homeostázou kationtů alkalických kovů a rezistencí k antimykotikům u kvasinek rodu Candida

• Main Author: Elicharová, Hana
• Other Authors: Buchta, Vladimír
• Format: Dissertation
• Language: Czech
• Published: 2010
• Online Access: http://www.nusl.cz/ntk/nusl-282938

Charles University in Prague, Faculty of Pharmacy in Hradec Králové, Department of Biochemical Sciences Candidate: Hana Elicharová Supervisor: PharmDr. Tomáš Šimůnek, Ph.D.; Department of Biochemical Sciences, Faculty of Pharmacy in Hradec Králové, Charles University in Prague Supervisor specialist: RNDr. Hana Sychrová, DrSc.; Department of Membrane Transport, Institute of Physiology AS CR, v.v.i. Title of diploma thesis: Relation between alkali-metal-cation homeostasis and resistance to antimycotics in Candida species The family of Candida species, normally a harmless human commensal of the gastrointestinal and genitourinary tract, can become a human pathogen under certain circumstances. Mainly in immunocompromised patients, Candida cause a wide range of infections and are the most prevalent pathogenic yeast. In this work we have focused on the most common Candida species (C. albicans, C. parapsilosis and C. glabrata) and we included C. dubliniensis as well. Candida species differ in their resistance to azole-antimycotics and their halotolerance. Azoles form the most important group of drugs with antifungal activity. They destabilise plasma membrane of Candida cells. The essential function of plasma membrane is regulation of cation homeostasis. The combination of subinhibition concentrations of...