Studium vlivu objemu roztoku na hmotnost očních kapek

• Main Author: Luknárová, Radka
• Other Authors: Šklubalová, Zdeňka
• Format: Dissertation
• Language: Czech
• Published: 2008
• Online Access: http://www.nusl.cz/ntk/nusl-292562

Study of influence of the solution volume on weight of eye drops Radka Luknárová Summary The work was focused on the influence of three selected factores on weight of eye drops: type of liquid, dispensing angle and volume of liquid. The comercially available dropping system used for the purpose of this investigation was formed by white plastic vial and white plastic dropper tip. The weight of drop of water and comercially product ATROPIN POS® (containins 0,5% atropine sulphate) was measured under two dispensing angles (90ř and 45ř). According to gained results, the weight of drop was significantly lower in the case of Atropine sulphate solution (p < 0,01) then in the case of water. This can be explained by lower surface tension caused by the presence of antimicrobial preservative and surfactant Benzalkonium chloride. The average weight of Atropine sulphate solution was cca 33 mg when dropped under dispensing angle 90ř.When the dispensing angles was lowered to 45ř, the weight of solution was only 29 mg, which is significantly lower value (p < 0,01). On the other hand, no significant differences of weight of drop were found for different filling volumes ranging between 2 - 10 ml. The chosen dispensing system allowed for only little variability of weight of drop under standard conditions ( 90ř, dropping speed...