Možnosti časné diagnostiky profesionálního bronchiálního astmatu
Early diagnosis of occupational asthma is important especially for the prognosis of this disease. The confirmation of the diagnosis of occupational asthma is sometimes difficult using diagnostic methods available nowadays. That is why searching new methods is very important. Analysis of exhaled brea...
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2008
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Online Access: | http://www.nusl.cz/ntk/nusl-294613 |
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ndltd-nusl.cz-oai-invenio.nusl.cz-2946132018-10-03T04:29:34Z Možnosti časné diagnostiky profesionálního bronchiálního astmatu název v anglickém jazyce není uveden Klusáčková, Pavlína Pelclová, Daniela Hajduková, Zdeňka Vízek, Martin Early diagnosis of occupational asthma is important especially for the prognosis of this disease. The confirmation of the diagnosis of occupational asthma is sometimes difficult using diagnostic methods available nowadays. That is why searching new methods is very important. Analysis of exhaled breath condensate (EBC) by liquid chromatography combined with mass spectrometry enables the separate detection of cysteinyl leukotrienes (LT) - LTC4, LTD4, LTE4; LTB4 and 8-isoprostane. If patients with occupational asthma and controls were compared, only LTC4 was significantly higher among all EBC parameters studied in asthmatics (despite corticosteroid treatment). This marker could be used in the future diagnostics. Monitoring of 24-hours variability of EBC parameters in patients, in whom occupational asthma is suspected, showed relatively high intraindividual and interindividual variation. It is evident therefore, that if only one daily measurement in asthmatics would be possible (which is common in articles of several authors), it should be collected in the same period of day in all persons. In negative bronchoprovocation tests significant changes of EBC parameters were not found. The evaluation of positive bronchoprovocation tests was limited by small number of patients, however in five persons from six, the... 2008 info:eu-repo/semantics/doctoralThesis http://www.nusl.cz/ntk/nusl-294613 cze info:eu-repo/semantics/restrictedAccess |
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Czech |
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Doctoral Thesis |
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NDLTD |
description |
Early diagnosis of occupational asthma is important especially for the prognosis of this disease. The confirmation of the diagnosis of occupational asthma is sometimes difficult using diagnostic methods available nowadays. That is why searching new methods is very important. Analysis of exhaled breath condensate (EBC) by liquid chromatography combined with mass spectrometry enables the separate detection of cysteinyl leukotrienes (LT) - LTC4, LTD4, LTE4; LTB4 and 8-isoprostane. If patients with occupational asthma and controls were compared, only LTC4 was significantly higher among all EBC parameters studied in asthmatics (despite corticosteroid treatment). This marker could be used in the future diagnostics. Monitoring of 24-hours variability of EBC parameters in patients, in whom occupational asthma is suspected, showed relatively high intraindividual and interindividual variation. It is evident therefore, that if only one daily measurement in asthmatics would be possible (which is common in articles of several authors), it should be collected in the same period of day in all persons. In negative bronchoprovocation tests significant changes of EBC parameters were not found. The evaluation of positive bronchoprovocation tests was limited by small number of patients, however in five persons from six, the... |
author2 |
Pelclová, Daniela |
author_facet |
Pelclová, Daniela Klusáčková, Pavlína |
author |
Klusáčková, Pavlína |
spellingShingle |
Klusáčková, Pavlína Možnosti časné diagnostiky profesionálního bronchiálního astmatu |
author_sort |
Klusáčková, Pavlína |
title |
Možnosti časné diagnostiky profesionálního bronchiálního astmatu |
title_short |
Možnosti časné diagnostiky profesionálního bronchiálního astmatu |
title_full |
Možnosti časné diagnostiky profesionálního bronchiálního astmatu |
title_fullStr |
Možnosti časné diagnostiky profesionálního bronchiálního astmatu |
title_full_unstemmed |
Možnosti časné diagnostiky profesionálního bronchiálního astmatu |
title_sort |
možnosti časné diagnostiky profesionálního bronchiálního astmatu |
publishDate |
2008 |
url |
http://www.nusl.cz/ntk/nusl-294613 |
work_keys_str_mv |
AT klusackovapavlina moznosticasnediagnostikyprofesionalnihobronchialnihoastmatu AT klusackovapavlina nazevvanglickemjazyceneniuveden |
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1718759042171535360 |