Optimalizace postupu přípravy polyesterových nanočástic

• Main Author: Pilátová, Kristýna
• Other Authors: Dittrich, Milan
• Format: Dissertation
• Language: Czech
• Published: 2011
• Online Access: http://www.nusl.cz/ntk/nusl-298052

In the theoretical part of the diploma the attention paid to the preparation of polymer nanoparticles and the properties of polymeric nanoparticles. Work also focuses on various form of colloidal nanocarriers. The focus of the diploma lies in the experiment. The main aim of the thesis was to prepare detailed study of influence of a very low concentrations of anionic sodium laurylsulfate and cationic cetyltrimethylamonium bromide on size and zetapotential of nanoparticles prepared by emulsionsolvent - distribution method from terpolymer of DL-lactid acid, glycolic acid and tripenterthritol. It was shown that even at 0,05% concentration of the emulsifier biodegradable polyester nanoparticles can be prepared and that they are stable in the mother dispersive liquor for 48 hours, which is the period considerably exceeding the time limit neceséry for further processing. In the tested concentration range the simple parameter dependence of size of nanoparticles on the concentration of emulsifier was not proven. At the lower concentrations of emulsifier the dispersion of nanoparticles diminished the size in time, at a the higher concentration of 0,20% the optimum time dispersion in the time interval between 40 seconds and 60 seconds was found. In case of a long-term storage of nanoparticles there are...