| Summary: | Introduction Non-steroidal anti-inflammatory drug (NSAID)-induced enteropathy represents an important complication related to one of the most commonly used drugs worldwide. The prevalence has been underestimated for a long time due to previous diagnostic difficulties. Objective The main goal of our project was to evaluate the basic characteristics of NSAID- induced enteropathy as well as the benefit of capsule endoscopy in its diagnostics. Methods and results In the first, experimental, part of the dissertation, we elaborated methodology of capsule endoscopy in an experimental animal and checked it on 7 healthy pigs. Although normal enteroscopy pictures were found in all the animals, some limitations were identified. The markedly worse visibility of the small bowel mucosa, and incomplete evaluation were the main ones. A model of NSAID-induced enteropathy (using a 10-day per oral indomethacin administration - 400 mg/day) was projected and verified in 8 healthy pigs consecutively. The endoscopy findings were confirmed by means of autopsy. We revealed the presence of small intestinal mucosal lesions on capsule endoscopy in the majority of the experimental pigs (87.5%). The most frequent findings were mild mucosal injury (red spots and erosions) in 6/8 animals. These findings were confirmed in 50.0% at...
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