Systémový zánět v patogenezi Parkinsonovy choroby
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences University of Seville, Faculty of Pharmacy Department of Biochemistry and Molecular Biology Candidate: Karolína Veselá Supervisors: Prof. Dr. José Luis Venero Recio, Prof. Ing. Vladimír Wsól, Ph.D...
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ndltd-nusl.cz-oai-invenio.nusl.cz-3071032017-06-28T04:16:09Z Systémový zánět v patogenezi Parkinsonovy choroby Role of systemic inflammation in Parkinson's disease Veselá, Karolína Wsól, Vladimír Zemanová, Lucie Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences University of Seville, Faculty of Pharmacy Department of Biochemistry and Molecular Biology Candidate: Karolína Veselá Supervisors: Prof. Dr. José Luis Venero Recio, Prof. Ing. Vladimír Wsól, Ph.D Title of diploma thesis: Role of Systemic Inflammation in Parkinson's Disease. Parkinson's disease (PD) is the second most common ageing-related neurodegenerative disorder after Alzheimer's disease and the prevalence in population is increasing. The characteristic movement disorder is caused by selective dopaminergic neurons loss, while the mechanism of this neurodegeneration is not well understood. Increasing evidence points out the key role of vicious cycle of microglial overactivation and oxidative stress, while the questions "where it begins" and "how to stop it" remain without clear answers. This thesis investigates implication of peripheral inflammation as a deteriorating circumstance and possible inductor of brain inflammation and progressive dopaminergic neurodegeneration. We use mice model of Parkinson's disease employing single intraperitoneal injection of toxin N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) that induces specific degeneration of DA neurons and in contrast to other animal... 2012 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-307103 eng info:eu-repo/semantics/restrictedAccess |
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Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Biochemical Sciences University of Seville, Faculty of Pharmacy Department of Biochemistry and Molecular Biology Candidate: Karolína Veselá Supervisors: Prof. Dr. José Luis Venero Recio, Prof. Ing. Vladimír Wsól, Ph.D Title of diploma thesis: Role of Systemic Inflammation in Parkinson's Disease. Parkinson's disease (PD) is the second most common ageing-related neurodegenerative disorder after Alzheimer's disease and the prevalence in population is increasing. The characteristic movement disorder is caused by selective dopaminergic neurons loss, while the mechanism of this neurodegeneration is not well understood. Increasing evidence points out the key role of vicious cycle of microglial overactivation and oxidative stress, while the questions "where it begins" and "how to stop it" remain without clear answers. This thesis investigates implication of peripheral inflammation as a deteriorating circumstance and possible inductor of brain inflammation and progressive dopaminergic neurodegeneration. We use mice model of Parkinson's disease employing single intraperitoneal injection of toxin N-methyl-4-phenyl-1,2,3,6- tetrahydropyridine (MPTP) that induces specific degeneration of DA neurons and in contrast to other animal... |
author2 |
Wsól, Vladimír |
author_facet |
Wsól, Vladimír Veselá, Karolína |
author |
Veselá, Karolína |
spellingShingle |
Veselá, Karolína Systémový zánět v patogenezi Parkinsonovy choroby |
author_sort |
Veselá, Karolína |
title |
Systémový zánět v patogenezi Parkinsonovy choroby |
title_short |
Systémový zánět v patogenezi Parkinsonovy choroby |
title_full |
Systémový zánět v patogenezi Parkinsonovy choroby |
title_fullStr |
Systémový zánět v patogenezi Parkinsonovy choroby |
title_full_unstemmed |
Systémový zánět v patogenezi Parkinsonovy choroby |
title_sort |
systémový zánět v patogenezi parkinsonovy choroby |
publishDate |
2012 |
url |
http://www.nusl.cz/ntk/nusl-307103 |
work_keys_str_mv |
AT veselakarolina systemovyzanetvpatogeneziparkinsonovychoroby AT veselakarolina roleofsystemicinflammationinparkinsonsdisease |
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1718473380483563520 |