HPLC hodnocení vybraných léčiv V.
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: Jana Kašková Consultant: RNDr. Milan Mokrý, CSc. Title of Thesis: HPLC evaluation of some drugs V. This thesis is about looking for the optimal conditions for simulta...
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2012
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Online Access: | http://www.nusl.cz/ntk/nusl-308261 |
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ndltd-nusl.cz-oai-invenio.nusl.cz-3082612017-06-28T04:16:16Z HPLC hodnocení vybraných léčiv V. HPLC evaluation of select drugs V. Kašková, Jana Mokrý, Milan Sochor, Jaroslav Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: Jana Kašková Consultant: RNDr. Milan Mokrý, CSc. Title of Thesis: HPLC evaluation of some drugs V. This thesis is about looking for the optimal conditions for simultaneous HPLC analysis in combined tablets of amlodipin and atorvastatin with subsequent determination of their content. As the most suitable stacionary phase was chosen chromatographic column 125x4 mm I. D. contains Nucleosil 120-5 C 18, Macherey-Nagel, and the mobile phase formed by mixture of acetonitrile - disodium hydrogen phosphate dodecahydrate solution (0,025 mol/l) in the ratio 55:45, acidified with phosporic acid at pH 4,4 at a flow rate of 1,0 ml/min and temperature 25řC. Propylparaben was used as the most suitable internal standard. The detection was performed at 210 nm using an UV-VIS detector. At the determination of content of medicaments in tablets was found that used compounds were eluted in following order: propylparaben, atorvastatin and amlodipine besylate. 2012 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-308261 cze info:eu-repo/semantics/restrictedAccess |
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Dissertation |
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Candidate: Jana Kašková Consultant: RNDr. Milan Mokrý, CSc. Title of Thesis: HPLC evaluation of some drugs V. This thesis is about looking for the optimal conditions for simultaneous HPLC analysis in combined tablets of amlodipin and atorvastatin with subsequent determination of their content. As the most suitable stacionary phase was chosen chromatographic column 125x4 mm I. D. contains Nucleosil 120-5 C 18, Macherey-Nagel, and the mobile phase formed by mixture of acetonitrile - disodium hydrogen phosphate dodecahydrate solution (0,025 mol/l) in the ratio 55:45, acidified with phosporic acid at pH 4,4 at a flow rate of 1,0 ml/min and temperature 25řC. Propylparaben was used as the most suitable internal standard. The detection was performed at 210 nm using an UV-VIS detector. At the determination of content of medicaments in tablets was found that used compounds were eluted in following order: propylparaben, atorvastatin and amlodipine besylate. |
author2 |
Mokrý, Milan |
author_facet |
Mokrý, Milan Kašková, Jana |
author |
Kašková, Jana |
spellingShingle |
Kašková, Jana HPLC hodnocení vybraných léčiv V. |
author_sort |
Kašková, Jana |
title |
HPLC hodnocení vybraných léčiv V. |
title_short |
HPLC hodnocení vybraných léčiv V. |
title_full |
HPLC hodnocení vybraných léčiv V. |
title_fullStr |
HPLC hodnocení vybraných léčiv V. |
title_full_unstemmed |
HPLC hodnocení vybraných léčiv V. |
title_sort |
hplc hodnocení vybraných léčiv v. |
publishDate |
2012 |
url |
http://www.nusl.cz/ntk/nusl-308261 |
work_keys_str_mv |
AT kaskovajana hplchodnocenivybranychlecivv AT kaskovajana hplcevaluationofselectdrugsv |
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1718473531678785536 |