Interakce oligoesteru PLGA s vodným prostředím

• Main Author: Hašková, Veronika
• Other Authors: Dittrich, Milan
• Format: Dissertation
• Language: Czech
• Published: 2012
• Online Access: http://www.nusl.cz/ntk/nusl-310833

In the theoretical part of this diploma theses is described mechanism of drug release from biodegradable polymers and conditions which influence this release process. The other part of the theses is directed to the characterization of the methods of the enhancing or reducing of release intensity. The structure, properties, synthesis and use of PLGA copolymers are mentioned. In the experimental part is referred on the study of PLGA matrices degradation in the aqueous medium at temperature of 7řC. The results achieved at this low temperature are compared with the same results of the same matrices behavior measured at the same conditions differing in the temperature of 37řC. These results were provided by my colleague Lenka Rufferova. The parameters of the samples were the swelling and erosion kinetics and acid number time evolution in the one-to-seven days time interval. The weight of the tested polyester samples were 50, 100, 150, and 250 mg. The results supported the earlier findings concerning typical pulse behavior of oligoesters of D,L lactic acid and glycolic acid during the degradation process.