Stanovení myorelaxancíí rokuronia, vekuronia a pankuronia metodou kapilární elektroforézy s bezkontaktní vodivostní detekcí
Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Student: Lenka Böhmová Supervisor: Doc. RNDr. Miroslav Polášek, CSc. Title of Diploma Thesis: Determination of rocuronium, vecuronium and pancuronium muscle relaxants by capillary electrophoresis w...
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ndltd-nusl.cz-oai-invenio.nusl.cz-3108842017-06-28T04:16:29Z Stanovení myorelaxancíí rokuronia, vekuronia a pankuronia metodou kapilární elektroforézy s bezkontaktní vodivostní detekcí Determination of rocuronium, vecuronium and pancuronium muscle relaxants by capillary electrophoresis with contactless conductivity detection Böhmová, Lenka Polášek, Miroslav Pospíšilová, Marie Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Student: Lenka Böhmová Supervisor: Doc. RNDr. Miroslav Polášek, CSc. Title of Diploma Thesis: Determination of rocuronium, vecuronium and pancuronium muscle relaxants by capillary electrophoresis with contactless conductivity detection A new method of capillary zone electrophoresis with contactless conductivity detection for the determination of pancuronium bromide, vecuronium bromide and rocuronium bromide was developed. The separation was carried out in fused-silica capillary with internal diameter 50 µm, total length 75 cm and effective length 45 cm. Optimal background electrolyte was 30mM acetate buffer of pH 5,75 containing 20 mg/ml of hydroxypropyl-γ-cyclodextrin. Phenyltrimethylammonium iodide was used as internal standard. The separation was performed at 25řC, the applied voltage was 20 kV. The samples were injected hydrodynamically at 50 mbar for 6 s. Under such optimal conditions the separation took less than 4 min. Calibration curves were linear for all analytes in the range 50 - 250 µg/ml, the coefficients of correlation were in the range 0,9954 - 0,9983. The limits of detection were 13,2 µg/ml, 11,1 µg/ml and 11,3 µg/ml for pancuronium bromide, vecuronium bromide and rocuronium... 2012 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-310884 cze info:eu-repo/semantics/restrictedAccess |
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Dissertation |
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Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Student: Lenka Böhmová Supervisor: Doc. RNDr. Miroslav Polášek, CSc. Title of Diploma Thesis: Determination of rocuronium, vecuronium and pancuronium muscle relaxants by capillary electrophoresis with contactless conductivity detection A new method of capillary zone electrophoresis with contactless conductivity detection for the determination of pancuronium bromide, vecuronium bromide and rocuronium bromide was developed. The separation was carried out in fused-silica capillary with internal diameter 50 µm, total length 75 cm and effective length 45 cm. Optimal background electrolyte was 30mM acetate buffer of pH 5,75 containing 20 mg/ml of hydroxypropyl-γ-cyclodextrin. Phenyltrimethylammonium iodide was used as internal standard. The separation was performed at 25řC, the applied voltage was 20 kV. The samples were injected hydrodynamically at 50 mbar for 6 s. Under such optimal conditions the separation took less than 4 min. Calibration curves were linear for all analytes in the range 50 - 250 µg/ml, the coefficients of correlation were in the range 0,9954 - 0,9983. The limits of detection were 13,2 µg/ml, 11,1 µg/ml and 11,3 µg/ml for pancuronium bromide, vecuronium bromide and rocuronium... |
author2 |
Polášek, Miroslav |
author_facet |
Polášek, Miroslav Böhmová, Lenka |
author |
Böhmová, Lenka |
spellingShingle |
Böhmová, Lenka Stanovení myorelaxancíí rokuronia, vekuronia a pankuronia metodou kapilární elektroforézy s bezkontaktní vodivostní detekcí |
author_sort |
Böhmová, Lenka |
title |
Stanovení myorelaxancíí rokuronia, vekuronia a pankuronia metodou kapilární elektroforézy s bezkontaktní vodivostní detekcí |
title_short |
Stanovení myorelaxancíí rokuronia, vekuronia a pankuronia metodou kapilární elektroforézy s bezkontaktní vodivostní detekcí |
title_full |
Stanovení myorelaxancíí rokuronia, vekuronia a pankuronia metodou kapilární elektroforézy s bezkontaktní vodivostní detekcí |
title_fullStr |
Stanovení myorelaxancíí rokuronia, vekuronia a pankuronia metodou kapilární elektroforézy s bezkontaktní vodivostní detekcí |
title_full_unstemmed |
Stanovení myorelaxancíí rokuronia, vekuronia a pankuronia metodou kapilární elektroforézy s bezkontaktní vodivostní detekcí |
title_sort |
stanovení myorelaxancíí rokuronia, vekuronia a pankuronia metodou kapilární elektroforézy s bezkontaktní vodivostní detekcí |
publishDate |
2012 |
url |
http://www.nusl.cz/ntk/nusl-310884 |
work_keys_str_mv |
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