Formulace nanočásticových systémů s protimikrobním působením
Drug delivery as modern way of therapeutic application is important goal of contemporary pharmaceutical research. The very specific tailor-made drug carriers and special working methods are used. Parametrs which potentially influence nanoparticle size distribution and their zeta potential were studi...
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2011
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Online Access: | http://www.nusl.cz/ntk/nusl-311349 |
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ndltd-nusl.cz-oai-invenio.nusl.cz-3113492018-11-16T04:17:26Z Formulace nanočásticových systémů s protimikrobním působením Formulation of Nanoparticle Systems with Antimicrobial Agents Brambůrková, Eva Dittrich, Milan Podzimek, Štěpán Masteiková, Ruta Drug delivery as modern way of therapeutic application is important goal of contemporary pharmaceutical research. The very specific tailor-made drug carriers and special working methods are used. Parametrs which potentially influence nanoparticle size distribution and their zeta potential were studied. Nanoparticles were prepared by emulsion solvent distribution-evaporation method from commercially available, biocompatible and biodegradable polymer PDLLA (poly (DL-lactic acid)) and other polyesters branched on mannitol or pentaerythritol and polyurethanes synthesized at workplace. Polymers were dissolved in different organic solvents (dichlormethane, chloroform or mixture of both in mass ratio 1:1). Poloxamers and polyvinylalcohol with different molecular weight and different degree of hydrolysis, polysorbate 20, and lecithin from soya bean or from eggs as emulsifying agent were used. Nanoemulsion was prepared by homogenizer with stator and rotor. Particle size and zeta potential was measured by Zetasizer. This study demonstrates that monodisperse nanoparticles can be prepared by emulsion solvent distribution-evaporation method in various composition of organic and also aqueous phase. Dispersion process is modified by organic solvent and emulsifier used. Zeta potential was influenced by composition... 2011 info:eu-repo/semantics/doctoralThesis http://www.nusl.cz/ntk/nusl-311349 cze info:eu-repo/semantics/restrictedAccess |
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Czech |
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Doctoral Thesis |
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description |
Drug delivery as modern way of therapeutic application is important goal of contemporary pharmaceutical research. The very specific tailor-made drug carriers and special working methods are used. Parametrs which potentially influence nanoparticle size distribution and their zeta potential were studied. Nanoparticles were prepared by emulsion solvent distribution-evaporation method from commercially available, biocompatible and biodegradable polymer PDLLA (poly (DL-lactic acid)) and other polyesters branched on mannitol or pentaerythritol and polyurethanes synthesized at workplace. Polymers were dissolved in different organic solvents (dichlormethane, chloroform or mixture of both in mass ratio 1:1). Poloxamers and polyvinylalcohol with different molecular weight and different degree of hydrolysis, polysorbate 20, and lecithin from soya bean or from eggs as emulsifying agent were used. Nanoemulsion was prepared by homogenizer with stator and rotor. Particle size and zeta potential was measured by Zetasizer. This study demonstrates that monodisperse nanoparticles can be prepared by emulsion solvent distribution-evaporation method in various composition of organic and also aqueous phase. Dispersion process is modified by organic solvent and emulsifier used. Zeta potential was influenced by composition... |
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Dittrich, Milan |
author_facet |
Dittrich, Milan Brambůrková, Eva |
author |
Brambůrková, Eva |
spellingShingle |
Brambůrková, Eva Formulace nanočásticových systémů s protimikrobním působením |
author_sort |
Brambůrková, Eva |
title |
Formulace nanočásticových systémů s protimikrobním působením |
title_short |
Formulace nanočásticových systémů s protimikrobním působením |
title_full |
Formulace nanočásticových systémů s protimikrobním působením |
title_fullStr |
Formulace nanočásticových systémů s protimikrobním působením |
title_full_unstemmed |
Formulace nanočásticových systémů s protimikrobním působením |
title_sort |
formulace nanočásticových systémů s protimikrobním působením |
publishDate |
2011 |
url |
http://www.nusl.cz/ntk/nusl-311349 |
work_keys_str_mv |
AT bramburkovaeva formulacenanocasticovychsystemusprotimikrobnimpusobenim AT bramburkovaeva formulationofnanoparticlesystemswithantimicrobialagents |
_version_ |
1718791493298159616 |