Characterizace proteinových interakcí gamma-tubulinu a jejich funkce v acentrozomálních buňkách

• Main Author: Doskočilová, Anna
• Other Authors: Binarová, Pavla
• Format: Doctoral Thesis
• Language: English
• Published: 2012
• Online Access: http://www.nusl.cz/ntk/nusl-312176

The long term goal of the Laboratory of Functional Cytology is to characterize the roles of γ-tubulin in acentrosomal plant model. Besides characterizing γ-tubulin interactions with plant homologues of proteins of γ-tubulin complexes (GCPs) and determination of their canonical role in microtubule nucleation, we also collect the evidence for γ-tubulin association with proteins that are not directly involved in microtubule nucleation. These γ-tubulin interacting proteins have been of high interest since their characterization might provide a platform for understanding the novel, yet not fully understood functions of γ-tubulin. The major aim of the laboratory is to determine signalling that regulates γ-tubulin complexes and their role in multiple processes in plants. Specifically, the cell cycle regulatory signalling in regulation of microtubular cytoskeleton nucleation and organization is of high interest.