Studium plazmatické vazebnosti nově vyvíjených radiofarmak

Studium plazmatické vazebnosti nově vyvíjených radiofarmak

CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ Department of Pharmacology and Toxicology DIPLOMA THESIS: Study of plasma protein binding of new radiopharmaceuticals SUMMARY: The binding ability of two receptor specific peptides - 111 In - DOTA - minigastrin 45 and 177 Lu - DOTA -...

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Main Author: Šejnová, Barbora
Other Authors: Lázníček, Milan
Format: Dissertation
Language:Czech
Published: 2011
Online Access:http://www.nusl.cz/ntk/nusl-313265
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spelling ndltd-nusl.cz-oai-invenio.nusl.cz-3132652017-06-28T04:16:57Z Studium plazmatické vazebnosti nově vyvíjených radiofarmak Study of plasma protein binding of new radiopharmaceuticals Šejnová, Barbora Lázníček, Milan Melicharová, Ludmila CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ Department of Pharmacology and Toxicology DIPLOMA THESIS: Study of plasma protein binding of new radiopharmaceuticals SUMMARY: The binding ability of two receptor specific peptides - 111 In - DOTA - minigastrin 45 and 177 Lu - DOTA - bombesin - was studied by methods of equilibrium dialysis at 37řC and ultrafiltration in terms of interspecies comparison. Among selected animal species (rat, rabbit, bovine, human) was plasma protein binding completely different. Higher binding was observed for 111 In - DOTA - minigastrin 45. In comparison of both methods - higher values of binding were measured for both peptides and all species by ultrafiltration than by equilibrium dialysis. KEYWORDS: radiopharmaceuticals, plasma protein binding, equilibrium dialysis, ultrafiltration, 111 In - DOTA - minigastrin 45, 177 Lu - DOTA - bombesin Barbora Šejnová Hradec Králové 2011 2011 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-313265 cze info:eu-repo/semantics/restrictedAccess
collection NDLTD
language Czech
format Dissertation
sources NDLTD
description CHARLES UNIVERSITY IN PRAGUE FACULTY OF PHARMACY IN HRADEC KRÁLOVÉ Department of Pharmacology and Toxicology DIPLOMA THESIS: Study of plasma protein binding of new radiopharmaceuticals SUMMARY: The binding ability of two receptor specific peptides - 111 In - DOTA - minigastrin 45 and 177 Lu - DOTA - bombesin - was studied by methods of equilibrium dialysis at 37řC and ultrafiltration in terms of interspecies comparison. Among selected animal species (rat, rabbit, bovine, human) was plasma protein binding completely different. Higher binding was observed for 111 In - DOTA - minigastrin 45. In comparison of both methods - higher values of binding were measured for both peptides and all species by ultrafiltration than by equilibrium dialysis. KEYWORDS: radiopharmaceuticals, plasma protein binding, equilibrium dialysis, ultrafiltration, 111 In - DOTA - minigastrin 45, 177 Lu - DOTA - bombesin Barbora Šejnová Hradec Králové 2011
author2 Lázníček, Milan
author_facet Lázníček, Milan
Šejnová, Barbora
author Šejnová, Barbora
spellingShingle Šejnová, Barbora
Studium plazmatické vazebnosti nově vyvíjených radiofarmak
author_sort Šejnová, Barbora
title Studium plazmatické vazebnosti nově vyvíjených radiofarmak
title_short Studium plazmatické vazebnosti nově vyvíjených radiofarmak
title_full Studium plazmatické vazebnosti nově vyvíjených radiofarmak
title_fullStr Studium plazmatické vazebnosti nově vyvíjených radiofarmak
title_full_unstemmed Studium plazmatické vazebnosti nově vyvíjených radiofarmak
title_sort studium plazmatické vazebnosti nově vyvíjených radiofarmak
publishDate 2011
url http://www.nusl.cz/ntk/nusl-313265
work_keys_str_mv AT sejnovabarbora studiumplazmatickevazebnostinovevyvijenychradiofarmak
AT sejnovabarbora studyofplasmaproteinbindingofnewradiopharmaceuticals
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