Cyklotrimerizace alkynů a nitrilů v syntéze helikálních chirálních látek
The objective of this Thesis was to prepare dialkynenitriles 156 and 168 for the synthesis of aza[6]helicene 146 and 147 via intramolecular [2+2+2] co-cyclotrimerization. It was found that it is possible to use co-cycloisomerization of alkynedinitriles 182, 187, 192 and 195, a reaction so far not de...
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2013
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Online Access: | http://www.nusl.cz/ntk/nusl-324822 |
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ndltd-nusl.cz-oai-invenio.nusl.cz-3248222017-06-28T04:18:00Z Cyklotrimerizace alkynů a nitrilů v syntéze helikálních chirálních látek Cyclotrimerization of alkynes and nitriles in the synthesis of helically chiral compounds Klívar, Jiří Stará, Irena Tobrman, Tomáš The objective of this Thesis was to prepare dialkynenitriles 156 and 168 for the synthesis of aza[6]helicene 146 and 147 via intramolecular [2+2+2] co-cyclotrimerization. It was found that it is possible to use co-cycloisomerization of alkynedinitriles 182, 187, 192 and 195, a reaction so far not described in the literature, for the preparation of dibenzodiazahelicenes 148 and 149 and dioxadiazahelicenes 150 and 151 possessing a pyridazine subunit. Moreover, alkynedinitriles 152, 153, 154 and 155 were synthesized to further study of this co-cycloisomerization reaction. The Theoretical Part outlines some representative examples of methods for the preparation of azahelicenes and azoniumhelicenes, current development of [2+2+2] cocyclotrimerization in the synthesis of pyridine derivatives and methods of pyridazine synthesis. The syntheses of dialkynenitriles 156 a 168, diazahelicenes 148, 149, 150, 151 and alkynedinitriles 152, 153, 154 and 155 are described in the section Results and Discussion and Experimental Part. 2013 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-324822 cze info:eu-repo/semantics/restrictedAccess |
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Dissertation |
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The objective of this Thesis was to prepare dialkynenitriles 156 and 168 for the synthesis of aza[6]helicene 146 and 147 via intramolecular [2+2+2] co-cyclotrimerization. It was found that it is possible to use co-cycloisomerization of alkynedinitriles 182, 187, 192 and 195, a reaction so far not described in the literature, for the preparation of dibenzodiazahelicenes 148 and 149 and dioxadiazahelicenes 150 and 151 possessing a pyridazine subunit. Moreover, alkynedinitriles 152, 153, 154 and 155 were synthesized to further study of this co-cycloisomerization reaction. The Theoretical Part outlines some representative examples of methods for the preparation of azahelicenes and azoniumhelicenes, current development of [2+2+2] cocyclotrimerization in the synthesis of pyridine derivatives and methods of pyridazine synthesis. The syntheses of dialkynenitriles 156 a 168, diazahelicenes 148, 149, 150, 151 and alkynedinitriles 152, 153, 154 and 155 are described in the section Results and Discussion and Experimental Part. |
author2 |
Stará, Irena |
author_facet |
Stará, Irena Klívar, Jiří |
author |
Klívar, Jiří |
spellingShingle |
Klívar, Jiří Cyklotrimerizace alkynů a nitrilů v syntéze helikálních chirálních látek |
author_sort |
Klívar, Jiří |
title |
Cyklotrimerizace alkynů a nitrilů v syntéze helikálních chirálních látek |
title_short |
Cyklotrimerizace alkynů a nitrilů v syntéze helikálních chirálních látek |
title_full |
Cyklotrimerizace alkynů a nitrilů v syntéze helikálních chirálních látek |
title_fullStr |
Cyklotrimerizace alkynů a nitrilů v syntéze helikálních chirálních látek |
title_full_unstemmed |
Cyklotrimerizace alkynů a nitrilů v syntéze helikálních chirálních látek |
title_sort |
cyklotrimerizace alkynů a nitrilů v syntéze helikálních chirálních látek |
publishDate |
2013 |
url |
http://www.nusl.cz/ntk/nusl-324822 |
work_keys_str_mv |
AT klivarjiri cyklotrimerizacealkynuanitriluvsyntezehelikalnichchiralnichlatek AT klivarjiri cyclotrimerizationofalkynesandnitrilesinthesynthesisofhelicallychiralcompounds |
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1718474927127920640 |