Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody

Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Anna Drbohlavová Supervisor: Mgr. Marcela Vejsová, Ph.D. Diploma thesis title: Evaluation of activity of potentional antibacterial substances through the use of microdiluti...

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Main Author: Drbohlavová, Anna
Other Authors: Vejsová, Marcela
Format: Dissertation
Language:Czech
Published: 2013
Online Access:http://www.nusl.cz/ntk/nusl-325083
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spelling ndltd-nusl.cz-oai-invenio.nusl.cz-3250832017-06-28T04:18:01Z Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody Evaluation of activity of potentional antibacterial substances through the use of microdilution broth method Drbohlavová, Anna Vejsová, Marcela Křivčíková, Lucie Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Anna Drbohlavová Supervisor: Mgr. Marcela Vejsová, Ph.D. Diploma thesis title: Evaluation of activity of potentional antibacterial substances through the use of microdilution broth method Objective The occurrence of resistant bacteria strains is the global problem today, which influences everyone's life. One of the way, how to solve this problem, is to develop new effective antibacterial substances. The goal of the diploma thesis was to test 70 potencial medical drugs and find out their antibacterial activity against selected bacteria strains. Methods The minimal inhibitory concentrations of tested substances, affecting the growth of the most common 8 conditionally pathogenic bacteria, including significant resistant strains such as MRSA and Klebsiella pneumoniae producing extended specter beta lactamase, were monitored by microdilution broth method. Results Tested substances were divided into eight groups according to their chemical structure and then their antibacterial effect was compared. The most effective group was presented by salicylanilide and its derivates. The influence of the chemical structure and production of clot in growth medium of these substances on... 2013 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-325083 cze info:eu-repo/semantics/restrictedAccess
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description Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Bc. Anna Drbohlavová Supervisor: Mgr. Marcela Vejsová, Ph.D. Diploma thesis title: Evaluation of activity of potentional antibacterial substances through the use of microdilution broth method Objective The occurrence of resistant bacteria strains is the global problem today, which influences everyone's life. One of the way, how to solve this problem, is to develop new effective antibacterial substances. The goal of the diploma thesis was to test 70 potencial medical drugs and find out their antibacterial activity against selected bacteria strains. Methods The minimal inhibitory concentrations of tested substances, affecting the growth of the most common 8 conditionally pathogenic bacteria, including significant resistant strains such as MRSA and Klebsiella pneumoniae producing extended specter beta lactamase, were monitored by microdilution broth method. Results Tested substances were divided into eight groups according to their chemical structure and then their antibacterial effect was compared. The most effective group was presented by salicylanilide and its derivates. The influence of the chemical structure and production of clot in growth medium of these substances on...
author2 Vejsová, Marcela
author_facet Vejsová, Marcela
Drbohlavová, Anna
author Drbohlavová, Anna
spellingShingle Drbohlavová, Anna
Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody
author_sort Drbohlavová, Anna
title Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody
title_short Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody
title_full Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody
title_fullStr Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody
title_full_unstemmed Vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody
title_sort vyhodnocení aktivity potenciálně antibakteriálních látek pomocí mikrodiluční bujónové metody
publishDate 2013
url http://www.nusl.cz/ntk/nusl-325083
work_keys_str_mv AT drbohlavovaanna vyhodnoceniaktivitypotencialneantibakterialnichlatekpomocimikrodilucnibujonovemetody
AT drbohlavovaanna evaluationofactivityofpotentionalantibacterialsubstancesthroughtheuseofmicrodilutionbrothmethod
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