Bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene Wistar po celotělovém a lokálním ozáření plic
6 3 SUMMARY Bioindicators of inflammation, oxidative and nitrossative stress in Wistar rats after whole-body and lung irradiation Introduction Radiation pneumonitis and fibrosis limitthe intensity of radiotherapy,increase morbidity and worsen quality of life of patients with lung and breast cancer o...
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Online Access: | http://www.nusl.cz/ntk/nusl-329250 |
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ndltd-nusl.cz-oai-invenio.nusl.cz-3292502021-02-26T05:20:09Z Bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene Wistar po celotělovém a lokálním ozáření plic Bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene Wistar po celotělovém a lokálním ozáření plic Nagy, Andrea Chládek, Jaroslav Hofer, Michal Štětina, Rudolf 6 3 SUMMARY Bioindicators of inflammation, oxidative and nitrossative stress in Wistar rats after whole-body and lung irradiation Introduction Radiation pneumonitis and fibrosis limitthe intensity of radiotherapy,increase morbidity and worsen quality of life of patients with lung and breast cancer or Hodgkin's disease. Radiation pneumonitis is an acute inflammatory reaction that resolves either spontaneously or after treatment with corticosteroids. Free radicals play an important role in its etiology. They cause dose-dependent induction of lipoperoxidation, DNA damage, activation of proapoptotic events and changes in activity of enzymes. The inflammatory reaction initiated by free radicals affects primarily epithelial and inflammatory cells, which release a number of cytokines (TNF-α, IL-1, IL-6, TGF-β, etc.). Radiation fibrosis of lungdevelops as a late consequence of radiotherapy (> 3 months). It can lead to chronic respiratory failureand death. Macroscopic findingsincludefibroblastproliferation,collagen deposition and destruction of lung parenchyma. Aims and methodology This work was focused on the changes in the arginine-nitric oxide metabolic pathway induced in the airways, lung and other parts of the body by ionizing gamma radiation in the early phase (within 72 h) as well as in the phase of radiation... 2013 info:eu-repo/semantics/doctoralThesis http://www.nusl.cz/ntk/nusl-329250 eng info:eu-repo/semantics/restrictedAccess |
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English |
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Doctoral Thesis |
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6 3 SUMMARY Bioindicators of inflammation, oxidative and nitrossative stress in Wistar rats after whole-body and lung irradiation Introduction Radiation pneumonitis and fibrosis limitthe intensity of radiotherapy,increase morbidity and worsen quality of life of patients with lung and breast cancer or Hodgkin's disease. Radiation pneumonitis is an acute inflammatory reaction that resolves either spontaneously or after treatment with corticosteroids. Free radicals play an important role in its etiology. They cause dose-dependent induction of lipoperoxidation, DNA damage, activation of proapoptotic events and changes in activity of enzymes. The inflammatory reaction initiated by free radicals affects primarily epithelial and inflammatory cells, which release a number of cytokines (TNF-α, IL-1, IL-6, TGF-β, etc.). Radiation fibrosis of lungdevelops as a late consequence of radiotherapy (> 3 months). It can lead to chronic respiratory failureand death. Macroscopic findingsincludefibroblastproliferation,collagen deposition and destruction of lung parenchyma. Aims and methodology This work was focused on the changes in the arginine-nitric oxide metabolic pathway induced in the airways, lung and other parts of the body by ionizing gamma radiation in the early phase (within 72 h) as well as in the phase of radiation... |
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Chládek, Jaroslav |
author_facet |
Chládek, Jaroslav Nagy, Andrea |
author |
Nagy, Andrea |
spellingShingle |
Nagy, Andrea Bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene Wistar po celotělovém a lokálním ozáření plic |
author_sort |
Nagy, Andrea |
title |
Bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene Wistar po celotělovém a lokálním ozáření plic |
title_short |
Bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene Wistar po celotělovém a lokálním ozáření plic |
title_full |
Bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene Wistar po celotělovém a lokálním ozáření plic |
title_fullStr |
Bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene Wistar po celotělovém a lokálním ozáření plic |
title_full_unstemmed |
Bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene Wistar po celotělovém a lokálním ozáření plic |
title_sort |
bioindikátory zánětu, oxidačního a nitračního stresu u potkana kmene wistar po celotělovém a lokálním ozáření plic |
publishDate |
2013 |
url |
http://www.nusl.cz/ntk/nusl-329250 |
work_keys_str_mv |
AT nagyandrea bioindikatoryzanetuoxidacnihoanitracnihostresuupotkanakmenewistarpocelotelovemalokalnimozareniplic |
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1719380238481227776 |