| Summary: | Charles Univerzity in Prague, Faculty of Pharmacy in Hradec Králové Department: Department of Biophysics and Physical Chemistry Candidate: Petra Reimerová Supervisor: PharmDr. Veronika Nováková, Ph.D. Title of Thesis: Comparison of Photophysical Properties of Different Types of Azaphthalocyanines Phthalocyanines and their aza-analogues azaphthalocyanines are organic dyes with planar macrocyclic structure and metal cation coordinated in the center. They can be used in many applications - for example as sensors, dyes or sensitizers in photodynamic therapy. The aim of this study was to compare photophysical properties (absorption, fluorescence, singlet oxygen production), solubility, aggregation and acid-base properties of several molecules 1-7 that differ in the type of macrocyclic core (see Figure below). The strength of absorption expressed as an extinction coefficient increased with the bathochromic shift of the Q-band. The position of the Q band depended on the number of conjugated double bonds and on the position of the peripheral substituents. Isosteric exchange of benzene rings to pyrazine rings shifted Q-band to shorter wavelength. Quantum yields of singlet oxygen (Φ∆) and quantum yields of fluorescence (ΦF) were determined in pyridine and THF by comparative method with ZnPc as a reference....
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