Farmakologické ovlivnění aterogeneze u experimentálních zvířecích modelů ateroskleózy
Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Jana Rathouská Supervisor: Doc. PharmDr. Petr Nachtigal, Ph.D. Title of Doctoral Thesis: Pharmacological influence on atherogenesis in experimental animal models of athero...
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2014
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ndltd-nusl.cz-oai-invenio.nusl.cz-3345722018-11-16T04:17:47Z Farmakologické ovlivnění aterogeneze u experimentálních zvířecích modelů ateroskleózy Pharmacological Influence on Atherogenesis in Experimental Animal Models of Atherosclerosis Rathouská, Jana Nachtigal, Petr Vrablík, Michal Vohnout, Branislav Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Jana Rathouská Supervisor: Doc. PharmDr. Petr Nachtigal, Ph.D. Title of Doctoral Thesis: Pharmacological influence on atherogenesis in experimental animal models of atherosclerosis Atherosclerosis is a slow inflammatory process in arterial walls which is, as a part of cardiovascular diseases, the main source of morbidity and mortality in developed countries. However, searching for the possibilities of atherosclerosis treatment requires detailed knowledge of pathogenesis of the disease itself. The use of mouse models offers one of the possibilities of studying the pathogenesis of atherosclerosis, which enables a number of interventions that would not be acceptable in human medicine. By using the high content lipid diet, we are able to induce the changes of lipid spectrum in mice. Moreover, if a targeted genetic manipulation is used, one can reach considerably advanced plaques in a relatively short time period. It is also possible to interfere in the process of atherogenesis in mouse models by using some hypolipidemic drugs, for example from the statin group that were represented in our studies by atorvastatin. By observing the vessel's reactivity to atorvastatin dosage,... 2014 info:eu-repo/semantics/doctoralThesis http://www.nusl.cz/ntk/nusl-334572 cze info:eu-repo/semantics/restrictedAccess |
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Doctoral Thesis |
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Charles University in Prague Faculty of Pharmacy in Hradec Králové Department of Biological and Medical Sciences Candidate: Mgr. Jana Rathouská Supervisor: Doc. PharmDr. Petr Nachtigal, Ph.D. Title of Doctoral Thesis: Pharmacological influence on atherogenesis in experimental animal models of atherosclerosis Atherosclerosis is a slow inflammatory process in arterial walls which is, as a part of cardiovascular diseases, the main source of morbidity and mortality in developed countries. However, searching for the possibilities of atherosclerosis treatment requires detailed knowledge of pathogenesis of the disease itself. The use of mouse models offers one of the possibilities of studying the pathogenesis of atherosclerosis, which enables a number of interventions that would not be acceptable in human medicine. By using the high content lipid diet, we are able to induce the changes of lipid spectrum in mice. Moreover, if a targeted genetic manipulation is used, one can reach considerably advanced plaques in a relatively short time period. It is also possible to interfere in the process of atherogenesis in mouse models by using some hypolipidemic drugs, for example from the statin group that were represented in our studies by atorvastatin. By observing the vessel's reactivity to atorvastatin dosage,... |
author2 |
Nachtigal, Petr |
author_facet |
Nachtigal, Petr Rathouská, Jana |
author |
Rathouská, Jana |
spellingShingle |
Rathouská, Jana Farmakologické ovlivnění aterogeneze u experimentálních zvířecích modelů ateroskleózy |
author_sort |
Rathouská, Jana |
title |
Farmakologické ovlivnění aterogeneze u experimentálních zvířecích modelů ateroskleózy |
title_short |
Farmakologické ovlivnění aterogeneze u experimentálních zvířecích modelů ateroskleózy |
title_full |
Farmakologické ovlivnění aterogeneze u experimentálních zvířecích modelů ateroskleózy |
title_fullStr |
Farmakologické ovlivnění aterogeneze u experimentálních zvířecích modelů ateroskleózy |
title_full_unstemmed |
Farmakologické ovlivnění aterogeneze u experimentálních zvířecích modelů ateroskleózy |
title_sort |
farmakologické ovlivnění aterogeneze u experimentálních zvířecích modelů ateroskleózy |
publishDate |
2014 |
url |
http://www.nusl.cz/ntk/nusl-334572 |
work_keys_str_mv |
AT rathouskajana farmakologickeovlivneniaterogenezeuexperimentalnichzvirecichmodeluateroskleozy AT rathouskajana pharmacologicalinfluenceonatherogenesisinexperimentalanimalmodelsofatherosclerosis |
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1718791562703405056 |