Stanovení potenciálních léčiv v biologickém materiálu

Stanovení potenciálních léčiv v biologickém materiálu

Charles University of Prague Fakulty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Candidate: Jana Suchardová Consultant: Ing. Vladimír Kubíček, CSc. The aim of this diploma thesis was to find suitable conditions for HPLC determination of VN 014 in biological matrices...

Full description

Bibliographic Details
Main Author: Suchardová, Jana
Other Authors: Kubíček, Vladimír
Format: Dissertation
Language:Czech
Published: 2014
Online Access:http://www.nusl.cz/ntk/nusl-337411
id ndltd-nusl.cz-oai-invenio.nusl.cz-337411
record_format oai_dc
spelling ndltd-nusl.cz-oai-invenio.nusl.cz-3374112017-06-28T04:19:36Z Stanovení potenciálních léčiv v biologickém materiálu Determination of Potential Drugs in Biological Matrices Suchardová, Jana Kubíček, Vladimír Lázníčková, Alice Charles University of Prague Fakulty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Candidate: Jana Suchardová Consultant: Ing. Vladimír Kubíček, CSc. The aim of this diploma thesis was to find suitable conditions for HPLC determination of VN 014 in biological matrices. Experiments were carried out on four core-shell columns (Ascentis® Express F5, Ascentis® Express C18, Ascentis® Express Phenyl-Hexyl, Ascentis® Express RP-Amide) with different mobile phases. In this thesis two extraction methods were also tested - solid phase extraction and liquid-liquid extraction. The best results were achieved on Ascentis® Express RP-Amide column with the mobile phase composed of 0.03 mol/l formic acid and methanol. LLE method was chosen for the sample preparation. Key words: HPLC, core-shell columns, SPE, LLE, RP-Amide 2014 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-337411 cze info:eu-repo/semantics/restrictedAccess
collection NDLTD
language Czech
format Dissertation
sources NDLTD
description Charles University of Prague Fakulty of Pharmacy in Hradec Králové Department of Biophysics and Physical Chemistry Candidate: Jana Suchardová Consultant: Ing. Vladimír Kubíček, CSc. The aim of this diploma thesis was to find suitable conditions for HPLC determination of VN 014 in biological matrices. Experiments were carried out on four core-shell columns (Ascentis® Express F5, Ascentis® Express C18, Ascentis® Express Phenyl-Hexyl, Ascentis® Express RP-Amide) with different mobile phases. In this thesis two extraction methods were also tested - solid phase extraction and liquid-liquid extraction. The best results were achieved on Ascentis® Express RP-Amide column with the mobile phase composed of 0.03 mol/l formic acid and methanol. LLE method was chosen for the sample preparation. Key words: HPLC, core-shell columns, SPE, LLE, RP-Amide
author2 Kubíček, Vladimír
author_facet Kubíček, Vladimír
Suchardová, Jana
author Suchardová, Jana
spellingShingle Suchardová, Jana
Stanovení potenciálních léčiv v biologickém materiálu
author_sort Suchardová, Jana
title Stanovení potenciálních léčiv v biologickém materiálu
title_short Stanovení potenciálních léčiv v biologickém materiálu
title_full Stanovení potenciálních léčiv v biologickém materiálu
title_fullStr Stanovení potenciálních léčiv v biologickém materiálu
title_full_unstemmed Stanovení potenciálních léčiv v biologickém materiálu
title_sort stanovení potenciálních léčiv v biologickém materiálu
publishDate 2014
url http://www.nusl.cz/ntk/nusl-337411
work_keys_str_mv AT suchardovajana stanovenipotencialnichlecivvbiologickemmaterialu
AT suchardovajana determinationofpotentialdrugsinbiologicalmatrices
_version_ 1718476228885741568

Similar Items