Využití moderních separačních metod pro klinické účely

Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical chemistry Candidate Mgr. Barbora Honegrová Supervisor prof. RNDr. Petr Solich, CSc. Title of Doctoral Thesis Using of modern separation methods for clinical practice This work is focused on the development o...

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Main Author: Honegrová, Barbora
Other Authors: Solich, Petr
Format: Doctoral Thesis
Language:Czech
Published: 2016
Online Access:http://www.nusl.cz/ntk/nusl-347515
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spelling ndltd-nusl.cz-oai-invenio.nusl.cz-3475152021-03-29T05:12:42Z Využití moderních separačních metod pro klinické účely Using of modern separation methods for clinical practice Honegrová, Barbora Solich, Petr Malíř, František Štěrbová, Petra Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical chemistry Candidate Mgr. Barbora Honegrová Supervisor prof. RNDr. Petr Solich, CSc. Title of Doctoral Thesis Using of modern separation methods for clinical practice This work is focused on the development of methods for the determination of vitamin A and E in biological materials using liquid chromatography. The theoretical background describes bioanalytical approaches to the determination of analytes from complex matrices. Sample preparation before analysis, chromatographic separation approaches and the validation of bioanalytical methods are discussed. The structure and biological function of target analytes are characterized. The experimental part contains three sections, two of them focus on the development of new chromatographic methods for the determination of vitamin A and E in biological samples such as serum, lipoprotein layers and breast milk. The aim is to find the most suitable conditions for the chromatographic separation of target analytes that will be used for clinical trials in University Hospital in Hradec Králové. The third section is concerned with monitoring the stability of vitamins in breast milk as well as the influence of pasteurisation and storage on levels of the target vitamins.... 2016 info:eu-repo/semantics/doctoralThesis http://www.nusl.cz/ntk/nusl-347515 cze info:eu-repo/semantics/restrictedAccess
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language Czech
format Doctoral Thesis
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description Charles University in Prague, Faculty of Pharmacy in Hradec Králové Department of Analytical chemistry Candidate Mgr. Barbora Honegrová Supervisor prof. RNDr. Petr Solich, CSc. Title of Doctoral Thesis Using of modern separation methods for clinical practice This work is focused on the development of methods for the determination of vitamin A and E in biological materials using liquid chromatography. The theoretical background describes bioanalytical approaches to the determination of analytes from complex matrices. Sample preparation before analysis, chromatographic separation approaches and the validation of bioanalytical methods are discussed. The structure and biological function of target analytes are characterized. The experimental part contains three sections, two of them focus on the development of new chromatographic methods for the determination of vitamin A and E in biological samples such as serum, lipoprotein layers and breast milk. The aim is to find the most suitable conditions for the chromatographic separation of target analytes that will be used for clinical trials in University Hospital in Hradec Králové. The third section is concerned with monitoring the stability of vitamins in breast milk as well as the influence of pasteurisation and storage on levels of the target vitamins....
author2 Solich, Petr
author_facet Solich, Petr
Honegrová, Barbora
author Honegrová, Barbora
spellingShingle Honegrová, Barbora
Využití moderních separačních metod pro klinické účely
author_sort Honegrová, Barbora
title Využití moderních separačních metod pro klinické účely
title_short Využití moderních separačních metod pro klinické účely
title_full Využití moderních separačních metod pro klinické účely
title_fullStr Využití moderních separačních metod pro klinické účely
title_full_unstemmed Využití moderních separačních metod pro klinické účely
title_sort využití moderních separačních metod pro klinické účely
publishDate 2016
url http://www.nusl.cz/ntk/nusl-347515
work_keys_str_mv AT honegrovabarbora vyuzitimodernichseparacnichmetodproklinickeucely
AT honegrovabarbora usingofmodernseparationmethodsforclinicalpractice
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