Vliv výživy na metabolismus kostí

• Main Author: Švejkovská, Klára
• Other Authors: Živná, Helena
• Format: Doctoral Thesis
• Language: Czech
• Published: 2015
• Online Access: http://www.nusl.cz/ntk/nusl-352251

The effect of nutrition on bone metabolism The bone has a function for support and protection, and is also a place for hematopoiesis and for mineral homeostasis. The subject of interest of this thesis is to evaluate the effect of chosen proteins, amino acids, iron and the conditions such as long-term under-nutrition, short-term starving and repeated blood withdrawals on the bone parameters - the length and the diameter of the bone, the width of corticalis, and the mechanical properties - resistance to bending, tension and torsion. There were evaluated changes in the concentration of bones markers, changes in the bone mineral density and changes in lean mass and adipose mass in healthy adult males of the Wistar rats . During my doctorate studies I was studying the effect of these components on the bones. In the 1st experiment the rats were fed by the chosen proteins and amino acids: glutamine (GLN), branched-chain amino acids- valine, leucine and izoleucine (BCAA), and caseine (KAS) ad libitum. Further we monitored the effect of one-week realimantation by standard laboratory diet (SLD) after long-term supplementation by the diet enriched by the above mentioned proteins and amino acids. The group fed by SLD ad libitum was the control group. In the 2nd experiment the effect of paired-feeding of the...