Příprava a hodnocení některých vlastností nových látek na bázi kvartérních amoniových solí

• Main Author: Nechanická, Aneta
• Other Authors: Doležal, Martin
• Format: Dissertation
• Language: Czech
• Published: 2017
• Online Access: http://www.nusl.cz/ntk/nusl-356024

Charles University, Faculty of Pharmacy in Hradec Králové Department of Pharmaceutical Chemistry and Drug Control Student: Aneta Nechanická Supervisor specialist: PharmDr. Jan Marek, Ph.D. Supervisor: prof. PharmDr. Martin Doležal, Ph.D. Title of Thesis: Synthesis and evaluation of novel compounds based on quaternary ammonium salts Five homologous series of quaternary ammonium salts were prepared by nucleophile reactions. As a starting material were used 1-(2-hydroxyethyl)pyrrolidine, 1- (2- hydroxyethyl)piperidine and 1-(2-hydroxyethyl)imidazole which reacted with C10-C18 bromalkyl reagents, in monoquaternary salts, and C8-C12 dibromalkyl reagents, in bisquaternary salts, with only even number of carbons. Products were verified by nuclear magnetic resonance (NMR) and high resolution mass spectrometry (HRMS). Critical micellar concentration (CMC) were measured by conductometry. Correlation between prolonging alkyl chain and CMC was confirmed.