Studium vhodnosti α-bromfenyloctové kyseliny jako modelového analytu pro chirální separace s využitím kapilární elektroforézy
Charles University Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Gabriela Kováčová Supervisor: PharmDr. Pavel Jáč, Ph.D. Title of diploma thesis: Study of α-bromphenylacetic acid suitability as a model analyte for chiral separations using capillary electrophores...
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2018
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Online Access: | http://www.nusl.cz/ntk/nusl-380636 |
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ndltd-nusl.cz-oai-invenio.nusl.cz-3806362021-03-29T05:12:58Z Studium vhodnosti α-bromfenyloctové kyseliny jako modelového analytu pro chirální separace s využitím kapilární elektroforézy Study of α-bromophenylacetic acid suitability as a model analyte for chiral separations using capillary electrophoresis as a separation technique Kováčová, Gabriela Jáč, Pavel Špulák, Marcel Charles University Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Gabriela Kováčová Supervisor: PharmDr. Pavel Jáč, Ph.D. Title of diploma thesis: Study of α-bromphenylacetic acid suitability as a model analyte for chiral separations using capillary electrophoresis as a separation technique This thesis deals with the stability of α-bromphenylacetic acid, that was used as the model analyte for chiral separations using capillary electrophoresis as a separation technique (see reference Rizvi, S. A. A., Shamsi, A. S.. Synthesis, Characterisation, and Application of Chiral Ionic Liquids and Their Polymers in Micellar Electrokinetic Chromatography. Anal.Chem. 2006, Volume, 7061-7069). Stability of α- bromphenylacetic acid in methanol and in 50% aqueous methanolic solution has been studied by means of capillary zone electrophoresis under the employment of different background electrolytes (50 mM phosphate buffer at pH 7.5, 60 mM acetate buffer at pH 5.0 and 60 mM formate buffer at pH 3.0). The separation was conducted in 50 μm id fused-silica capillary. UV detection was at 200 nm. The successful separation of all theoreticaly possible products of nucleophilic substitution (mandelic acid, α- methoxyphenylacetic acid and bromide) has been reached only in the 60 mM... 2018 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-380636 cze info:eu-repo/semantics/restrictedAccess |
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Charles University Faculty of Pharmacy in Hradec Králové Department of Analytical Chemistry Candidate: Gabriela Kováčová Supervisor: PharmDr. Pavel Jáč, Ph.D. Title of diploma thesis: Study of α-bromphenylacetic acid suitability as a model analyte for chiral separations using capillary electrophoresis as a separation technique This thesis deals with the stability of α-bromphenylacetic acid, that was used as the model analyte for chiral separations using capillary electrophoresis as a separation technique (see reference Rizvi, S. A. A., Shamsi, A. S.. Synthesis, Characterisation, and Application of Chiral Ionic Liquids and Their Polymers in Micellar Electrokinetic Chromatography. Anal.Chem. 2006, Volume, 7061-7069). Stability of α- bromphenylacetic acid in methanol and in 50% aqueous methanolic solution has been studied by means of capillary zone electrophoresis under the employment of different background electrolytes (50 mM phosphate buffer at pH 7.5, 60 mM acetate buffer at pH 5.0 and 60 mM formate buffer at pH 3.0). The separation was conducted in 50 μm id fused-silica capillary. UV detection was at 200 nm. The successful separation of all theoreticaly possible products of nucleophilic substitution (mandelic acid, α- methoxyphenylacetic acid and bromide) has been reached only in the 60 mM... |
author2 |
Jáč, Pavel |
author_facet |
Jáč, Pavel Kováčová, Gabriela |
author |
Kováčová, Gabriela |
spellingShingle |
Kováčová, Gabriela Studium vhodnosti α-bromfenyloctové kyseliny jako modelového analytu pro chirální separace s využitím kapilární elektroforézy |
author_sort |
Kováčová, Gabriela |
title |
Studium vhodnosti α-bromfenyloctové kyseliny jako modelového analytu pro chirální separace s využitím kapilární elektroforézy |
title_short |
Studium vhodnosti α-bromfenyloctové kyseliny jako modelového analytu pro chirální separace s využitím kapilární elektroforézy |
title_full |
Studium vhodnosti α-bromfenyloctové kyseliny jako modelového analytu pro chirální separace s využitím kapilární elektroforézy |
title_fullStr |
Studium vhodnosti α-bromfenyloctové kyseliny jako modelového analytu pro chirální separace s využitím kapilární elektroforézy |
title_full_unstemmed |
Studium vhodnosti α-bromfenyloctové kyseliny jako modelového analytu pro chirální separace s využitím kapilární elektroforézy |
title_sort |
studium vhodnosti α-bromfenyloctové kyseliny jako modelového analytu pro chirální separace s využitím kapilární elektroforézy |
publishDate |
2018 |
url |
http://www.nusl.cz/ntk/nusl-380636 |
work_keys_str_mv |
AT kovacovagabriela studiumvhodnostiabromfenyloctovekyselinyjakomodelovehoanalytuprochiralniseparacesvyuzitimkapilarnielektroforezy AT kovacovagabriela studyofabromophenylaceticacidsuitabilityasamodelanalyteforchiralseparationsusingcapillaryelectrophoresisasaseparationtechnique |
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1719390181107171328 |