Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu
Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Candidate: Michal Kadaník Supervisor: Prof. RNDr. Milan Pour, Ph.D. Title of thesis: Nucleophile-Assisted Gold(I)-Catalyzed Cyclizations of Enynes This work is focused on gold(I)-catalyzed cycliza...
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ndltd-nusl.cz-oai-invenio.nusl.cz-4039312019-10-21T04:11:11Z Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu Nucleophile-Assisted Gold(I)-Catalyzed Cyclizations of Enynes Kadaník, Michal Pour, Milan Opálka, Lukáš Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Candidate: Michal Kadaník Supervisor: Prof. RNDr. Milan Pour, Ph.D. Title of thesis: Nucleophile-Assisted Gold(I)-Catalyzed Cyclizations of Enynes This work is focused on gold(I)-catalyzed cyclizations of substituted enyne in the presence of a nucleophile. The screening of various gold catalysts, silver co-catalysts, solvents and nucleophiles was performed. We achieved the formation of substituted tetrahydropyridine with excellent diastereoselectivity by optimization of the reaction conditions. To extend our methology, the second part deals with the gold(I)-catalyzed cyclization of the enyne with chiral center. The cyclization was found to be enantioselective. Keywords: gold catalysis, tetrahydropyridines, hemiaminals, hemiaminalethers 2019 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-403931 cze info:eu-repo/semantics/restrictedAccess |
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Dissertation |
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Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Candidate: Michal Kadaník Supervisor: Prof. RNDr. Milan Pour, Ph.D. Title of thesis: Nucleophile-Assisted Gold(I)-Catalyzed Cyclizations of Enynes This work is focused on gold(I)-catalyzed cyclizations of substituted enyne in the presence of a nucleophile. The screening of various gold catalysts, silver co-catalysts, solvents and nucleophiles was performed. We achieved the formation of substituted tetrahydropyridine with excellent diastereoselectivity by optimization of the reaction conditions. To extend our methology, the second part deals with the gold(I)-catalyzed cyclization of the enyne with chiral center. The cyclization was found to be enantioselective. Keywords: gold catalysis, tetrahydropyridines, hemiaminals, hemiaminalethers |
author2 |
Pour, Milan |
author_facet |
Pour, Milan Kadaník, Michal |
author |
Kadaník, Michal |
spellingShingle |
Kadaník, Michal Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu |
author_sort |
Kadaník, Michal |
title |
Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu |
title_short |
Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu |
title_full |
Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu |
title_fullStr |
Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu |
title_full_unstemmed |
Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu |
title_sort |
zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu |
publishDate |
2019 |
url |
http://www.nusl.cz/ntk/nusl-403931 |
work_keys_str_mv |
AT kadanikmichal zlatemkatalyzovanecyklizaceenynuvpritomnostinukleofilu AT kadanikmichal nucleophileassistedgoldicatalyzedcyclizationsofenynes |
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1719273218865364992 |