Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu

Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Candidate: Michal Kadaník Supervisor: Prof. RNDr. Milan Pour, Ph.D. Title of thesis: Nucleophile-Assisted Gold(I)-Catalyzed Cyclizations of Enynes This work is focused on gold(I)-catalyzed cycliza...

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Bibliographic Details
Main Author:	Kadaník, Michal
Other Authors:	Pour, Milan
Format:	Dissertation
Language:	Czech
Published:	2019
Online Access:	http://www.nusl.cz/ntk/nusl-403931

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spelling	ndltd-nusl.cz-oai-invenio.nusl.cz-4039312019-10-21T04:11:11Z Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu Nucleophile-Assisted Gold(I)-Catalyzed Cyclizations of Enynes Kadaník, Michal Pour, Milan Opálka, Lukáš Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Candidate: Michal Kadaník Supervisor: Prof. RNDr. Milan Pour, Ph.D. Title of thesis: Nucleophile-Assisted Gold(I)-Catalyzed Cyclizations of Enynes This work is focused on gold(I)-catalyzed cyclizations of substituted enyne in the presence of a nucleophile. The screening of various gold catalysts, silver co-catalysts, solvents and nucleophiles was performed. We achieved the formation of substituted tetrahydropyridine with excellent diastereoselectivity by optimization of the reaction conditions. To extend our methology, the second part deals with the gold(I)-catalyzed cyclization of the enyne with chiral center. The cyclization was found to be enantioselective. Keywords: gold catalysis, tetrahydropyridines, hemiaminals, hemiaminalethers 2019 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-403931 cze info:eu-repo/semantics/restrictedAccess
collection	NDLTD
language	Czech
format	Dissertation
sources	NDLTD
description	Charles University Faculty of Pharmacy in Hradec Králové Department of Organic and Bioorganic Chemistry Candidate: Michal Kadaník Supervisor: Prof. RNDr. Milan Pour, Ph.D. Title of thesis: Nucleophile-Assisted Gold(I)-Catalyzed Cyclizations of Enynes This work is focused on gold(I)-catalyzed cyclizations of substituted enyne in the presence of a nucleophile. The screening of various gold catalysts, silver co-catalysts, solvents and nucleophiles was performed. We achieved the formation of substituted tetrahydropyridine with excellent diastereoselectivity by optimization of the reaction conditions. To extend our methology, the second part deals with the gold(I)-catalyzed cyclization of the enyne with chiral center. The cyclization was found to be enantioselective. Keywords: gold catalysis, tetrahydropyridines, hemiaminals, hemiaminalethers
author2	Pour, Milan
author_facet	Pour, Milan Kadaník, Michal
author	Kadaník, Michal
spellingShingle	Kadaník, Michal Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu
author_sort	Kadaník, Michal
title	Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu
title_short	Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu
title_full	Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu
title_fullStr	Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu
title_full_unstemmed	Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu
title_sort	zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu
publishDate	2019
url	http://www.nusl.cz/ntk/nusl-403931
work_keys_str_mv	AT kadanikmichal zlatemkatalyzovanecyklizaceenynuvpritomnostinukleofilu AT kadanikmichal nucleophileassistedgoldicatalyzedcyclizationsofenynes
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Zlatem katalyzované cyklizace enynů v přítomnosti nukleofilu

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