Monitorování liberačních testů.
Charles University Faculty of Pharmacy in Hradci Králové Department of Analytical Chemistry Candidate: Marek Beran Supervisor: Doc. PharmDr. Hana Sklenářová, Ph.D. Consultant: Ing. Daniela Šmejkalová, Ph.D Title of Diploma Thesis: Monitoring of liberation tests The diploma thesis is focused on the d...
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ndltd-nusl.cz-oai-invenio.nusl.cz-4045312021-03-29T05:13:08Z Monitorování liberačních testů. Monitoring of liberation tests. Beran, Marek Sklenářová, Hana Matysová, Ludmila Charles University Faculty of Pharmacy in Hradci Králové Department of Analytical Chemistry Candidate: Marek Beran Supervisor: Doc. PharmDr. Hana Sklenářová, Ph.D. Consultant: Ing. Daniela Šmejkalová, Ph.D Title of Diploma Thesis: Monitoring of liberation tests The diploma thesis is focused on the development of an automated method for the monitoring of the dissolution profile of clotrimazole from topical dosage forms. The dissolution profile of formulations containing the antifungal agent clotrimazole are compared. Commercially available formulations Canesten and Clotrimazol AL in the form of creams, are compared with a new formulation called Delcore from Contipro a.s., which contains a complex matrix. Theoretical part addresses mycotic infections with focus on superficial mycoses and products available on the Czech market for the treatment of those infections. Furthermore, there is a description of selected non-separation flow methods. The analysis was carried out in a sequential injection analysis system coupled with three attached Franz dissolution cells with a membrane on which the sample was applied. The Franz cells were placed in a water bath at 32 řC. Phosphate buffer with pH 7.4 was chosen as the dissolution medium as it partially imitates the conditions of the human environment. Detection... 2019 info:eu-repo/semantics/masterThesis http://www.nusl.cz/ntk/nusl-404531 cze info:eu-repo/semantics/restrictedAccess |
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Dissertation |
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Charles University Faculty of Pharmacy in Hradci Králové Department of Analytical Chemistry Candidate: Marek Beran Supervisor: Doc. PharmDr. Hana Sklenářová, Ph.D. Consultant: Ing. Daniela Šmejkalová, Ph.D Title of Diploma Thesis: Monitoring of liberation tests The diploma thesis is focused on the development of an automated method for the monitoring of the dissolution profile of clotrimazole from topical dosage forms. The dissolution profile of formulations containing the antifungal agent clotrimazole are compared. Commercially available formulations Canesten and Clotrimazol AL in the form of creams, are compared with a new formulation called Delcore from Contipro a.s., which contains a complex matrix. Theoretical part addresses mycotic infections with focus on superficial mycoses and products available on the Czech market for the treatment of those infections. Furthermore, there is a description of selected non-separation flow methods. The analysis was carried out in a sequential injection analysis system coupled with three attached Franz dissolution cells with a membrane on which the sample was applied. The Franz cells were placed in a water bath at 32 řC. Phosphate buffer with pH 7.4 was chosen as the dissolution medium as it partially imitates the conditions of the human environment. Detection... |
author2 |
Sklenářová, Hana |
author_facet |
Sklenářová, Hana Beran, Marek |
author |
Beran, Marek |
spellingShingle |
Beran, Marek Monitorování liberačních testů. |
author_sort |
Beran, Marek |
title |
Monitorování liberačních testů. |
title_short |
Monitorování liberačních testů. |
title_full |
Monitorování liberačních testů. |
title_fullStr |
Monitorování liberačních testů. |
title_full_unstemmed |
Monitorování liberačních testů. |
title_sort |
monitorování liberačních testů. |
publishDate |
2019 |
url |
http://www.nusl.cz/ntk/nusl-404531 |
work_keys_str_mv |
AT beranmarek monitorovaniliberacnichtestu AT beranmarek monitoringofliberationtests |
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1719390355276693504 |