Vliv podávání progesteronu na T regulační buňky ve vztahu k předčasným porodům
During pregnancy, the maternal organism has to cope with the presence of foreign paternal antigens, allow and support the development of a semialogenic fetus, while maintaining its defense against pathogens. This condition is achieved by a dynamic balance of complex immuno-endocrine interactions. A...
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| Format: | Dissertation |
| Language: | Czech |
| Published: |
2019
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| Online Access: | http://www.nusl.cz/ntk/nusl-405205 |
| Summary: | During pregnancy, the maternal organism has to cope with the presence of foreign paternal antigens, allow and support the development of a semialogenic fetus, while maintaining its defense against pathogens. This condition is achieved by a dynamic balance of complex immuno-endocrine interactions. A number of cells with specific properties contributes to the tolerogenic setting during pregnancy. Very important role plays the population of T regulatory lymphocytes (Treg). Treg levels increase physiologically during pregnancy and their decline is associated with term and preterm labor. Premature birth is a serious socio-economic problem, affecting around 10 % of births worldwide. In the case of increased risk of premature labor, progesterone administration has been successfully used in clinical practice. One hypothesis says that progesterone induces an increase in Treg population and delays premature labor in this way. The aim of the thesis was to monitor the effect of progesterone therapy in vivo on the amount and functional properties of CD4+ CD25+ FoxP3+ Helios+/- Treg and to verify whether long-term vaginal administration of progesterone positively correlates with an increase in Treg counts. Another goal was to determine whether progesterone promotes Treg generation and the production of... |
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