Hladiny specifických protilátek proti spalničkám u zaměstnanců fakultní nemocnice v době rizika jejich návratu

• Main Author: Malinová, Jana
• Other Authors: Čelko, Alexander
• Format: Doctoral Thesis
• Language: Czech
• Published: 2020
• Online Access: http://www.nusl.cz/ntk/nusl-436421

Levels of specific antibodies against measles, in university hospital staff, during the 2018-2019 measles outbreak in Prague, CZ. MUDr. Jana Malinová Between May 2018 and December 2019, during an epidemic measles outbreak in the Czech Republic, especially in Prague, a prospective serological study was conducted by staff at the Kralovske University Hospital, which focused on determining the measles seropositivity of the Kralovske University Hospital personal. During the study, a total of 2,782 university hospital employees, between the ages of 19-89 years, were examined. The aim of the study was to determine whether the measles seropositivity rate in health care staff was greater than 90 % and whether seropositivity was affected by any of the studied variables such as gender, age, natural vs. acquired immunity, overweight or obesity, smoking, and concomitant disease. Since childhood immunity, obtained either by infection or vaccination, was assumed, seropositivity persistence into adulthood was also evaluated. The results of the study confirmed that the seropositivity of medical personnel was greater than 90 % independently of how it was acquired. However, seropositivity was higher (98 %) in those who had natural immunity via a childhood measles infection. Although vaccination with at least one dose of the...